SynthesisCNS drugs2014
Drug-induced cerebellar ataxia: a systematic review.
Synthesis in CNS drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Cerebellar Degeneration in Epilepsy: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Protective effect of dapagliflozin against phenytoin-induced cerebellar dysfunction and histological alterations in rats: the role of SIRT1/Nrf2/HO-1 pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Co-occurrence of Neuroleptic Malignant Syndrome and Silent Syndrome in a Patient With Bipolar Disorder: Clinical Challenges and Long-term Neurological Sequelae.Cerebellum (London, England) · 2026Article
- Progress and challenges in sporadic late-onset cerebellar ataxias.Nature reviews. Neurology · 2025Review
- Early acute cerebellar ataxia after meningococcal B vaccine: a case report of a 7-month-old infant and a review of the literature.Italian journal of pediatrics · 2023Review
- Ataxias: Hereditary, Acquired, and Reversible Etiologies.Seminars in neurology · 2023Article
- Ataxia in Neurometabolic Disorders.Metabolites · 2022Review
- Falls in community-dwelling women with bipolar disorder: a case-control study.BMC psychiatry · 2022Article
- Post-infectious cerebellar ataxia following COVID-19 in a patient with epilepsy.Clinical & experimental neuroimmunology · 2022Article
- Differences in brain changes between adults with childhood-onset epilepsy and controls: A prospective population-based study.Acta neurologica Scandinavica · 2022Article
- Spinocerebellar ataxia type 23 (SCA23): a review.Journal of neurology · 2021Review
- Article
- The Developing Cerebellum as a Target for Toxic Substances: Protective Role of Antioxidants.Cerebellum (London, England) · 2021Review
- Paroxysmal Genetic Movement Disorders and Epilepsy.Frontiers in neurology · 2021Review
- Assessing Children with Poor Coordination Can Be Tricky - A Review on Ataxia and Ataxia Mimickers and a Study of Three Children with Severe Epilepsy.Journal of multidisciplinary healthcare · 2021Review
- Modeling cerebellar limb dysmetria and impaired spatial memory in rats using lamivudine: A preliminary study.Journal of chemical neuroanatomy · 2020Article
- Cognitive and sensorimotor function in participants being treated for trigeminal neuralgia pain.The journal of headache and pain · 2020Article
- Female sexual dysfunction associated with idiopathic cerebellar ataxia: A case report.BMC women's health · 2019Article
- Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs.Journal of veterinary internal medicine · 2019Article
- The neuropathology of the adult cerebellum.Handbook of clinical neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCerebellar ataxia can be induced by a large number of drugs. We here conducted a systemic review of the drugs that can lead to cerebellar ataxia as an adverse drug reaction (ADR).
methodsWe performed a systematic literature search in Pubmed (1966 to January 2014) and EMBASE (1988 to January 2014) to identify all of the drugs that can have ataxia as an ADR and to assess the frequency of drug-induced ataxia for individual drugs. Furthermore, we collected reports of drug-induced ataxia over the past 20 years in the Netherlands by querying a national register of ADRs.
resultsDrug-induced ataxia was reported in association with 93 individual drugs (57 from the literature, 36 from the Dutch registry). The most common groups were antiepileptic drugs, benzodiazepines, and antineoplastics. For some, the number needed to harm was below 10. Ataxia was commonly reversible, but persistent symptoms were described with lithium and certain antineoplastics.
conclusionsIt is important to be aware of the possibility that ataxia might be drug-induced, and for some drugs the relative frequency of this particular ADR is high. In most patients, symptoms occur within days or weeks after the introduction of a new drug or an increase in dose. In general, ataxia tends to disappear after discontinuation of the drug, but chronic ataxia has been described for some drugs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.