ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Deciphering estrogen receptor alpha-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape.F&S science · 2026Article
- Review
- Expression and role of nuclear receptor-interacting protein 1 (NRIP1) in stomach adenocarcinoma.Annals of translational medicine · 2020Article
- Circular RNA circNTRK2 facilitates the progression of esophageal squamous cell carcinoma through up-regulating NRIP1 expression via miR-140-3p.Journal of experimental & clinical cancer research : CR · 2020Article
- Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.International journal of molecular medicine · 2018Article
- Downregulation of RIP140 in triple-negative breast cancer inhibits the growth and proliferation of cancer cells.Oncology letters · 2018Article
- Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells.Oncology letters · 2018Article
- RIP140 and LCoR expression in gastrointestinal cancers.Oncotarget · 2017Article
- Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer.Oncotarget · 2017Article
- Expression and role of nuclear receptor coregulators in colorectal cancer.World journal of gastroenterology · 2017Review
- NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.Oncotarget · 2015Article
- The Expression of NRIP1 and LCOR in Endometrioid Endometrial Cancer.In vivo (Athens, Greece)Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel diagnosis biomarkers and therapeutic targets. RIP140, a regulator of estrogen receptor, recently has been found to be involved in the tumorigenesis. However, its function in the progression of HCC remains poorly understood. Here, we found that the expression of RIP140 was downregulated in the HCC tissues. Moreover, overexpression of RIP140 in HCC cells inhibited cell proliferation and migration, while downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro and in vivo. Mechanistically, RIP140 interacted with beta-catenin and negatively regulated beta-catenin/TCF signaling. Taken together, our study suggests the suppressive roles of RIP140 in the pathogenesis of HCC.
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