Evidence map›Paper›PMID 25391402›Full record

ArticleCarcinogenesis2015

Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde.

Qing Lan, Martyn T Smith, Xiaojiang Tang, Weihong Guo, Roel Vermeulen, Zhiying Ji, Wei Hu, Alan E Hubbard, Min Shen, Cliona M McHale and 12 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Effects of residual HRegenerative therapy · 2018
    Article
  16. Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia?Annals of occupational and environmental medicine · 2018
    Article
  17. Formaldehyde, Hematotoxicity, and Chromosomal Changes-Response.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 3 countries.

Qing LanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute (NIH), Bethesda, MD 20892, USA, Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, Science and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands, Department of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and Department of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China luoping@berkeley.edu qingl@mail.nih.gov.
Martyn T SmithDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA.
Xiaojiang TangScience and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China.
Weihong GuoDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA.
Roel VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands.
Zhiying JiDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA.
Wei HuOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute (NIH), Bethesda, MD 20892, USA, Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, Science and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands, Department of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and Department of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China.
Alan E HubbardDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA.
Min ShenOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute (NIH), Bethesda, MD 20892, USA, Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, Science and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands, Department of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and Department of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China.
Cliona M McHaleDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA.
Chuangyi QiuScience and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China.
Songwang LiuDepartment of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and.
Boris ReissDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands.
Laura Beane-FreemanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute (NIH), Bethesda, MD 20892, USA, Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, Science and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands, Department of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and Department of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China.
Aaron BlairOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute (NIH), Bethesda, MD 20892, USA, Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, Science and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands, Department of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and Department of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China.
Yichen GeScience and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China.
Jun XiongDepartment of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China.
Laiyu LiScience and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China.
Stephen M RappaportDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA.
Hanlin HuangScience and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China.
Nathaniel RothmanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute (NIH), Bethesda, MD 20892, USA, Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, Science and Education Department, Guangdong Poisoning Control Center, Guangzhou 510300, China, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands, Department of Occupational Health, Qiaotou Hospital, Dongguan, Guangdong 523323, China and Department of Occupational Health, Dongguan Center for Disease Control and Prevention, Guangdong 523129, China.
Luoping ZhangDivision of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA, luoping@berkeley.edu qingl@mail.nih.gov.
Division of Cancer Epidemiology and GeneticsGuangzhou Center for Disease Control and Prevention · CNUtrecht University · NLNational Cancer Institute · US

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MORELLO-FROSCH, RACHEL ADELE · 1987 to 2025
$74.6M
Molecular Epidemiology Studies of Occupational and Environmental ExposuresZIACP010121 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ROTHMAN, NATHANIEL · 2009 to 2025
$23.5M
Biomarkers of Formaldehyde Exposure and ToxicityR01ES017452 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, LUOPING · 2009 to 2010
$743k
Intramural NIH HHSNIEHS NIH HHS P42 ES004705NIEHS NIH HHS P42ES004705NIEHS NIH HHS R01 ES017452NIEHS NIH HHS R01ES017452
6 · The paper itself

Abstract

Formaldehyde (FA) is an economically important industrial chemical to which millions of people worldwide are exposed environmentally and occupationally. Recently, the International Agency for Cancer Research concluded that there is sufficient evidence that FA causes leukemia, particularly myeloid leukemia. To evaluate the biological plausibility of this association, we employed a chromosome-wide aneuploidy study approach, which allows the evaluation of aneuploidy and structural chromosome aberrations (SCAs) of all 24 chromosomes simultaneously, to analyze cultured myeloid progenitor cells from 29 workers exposed to relatively high levels of FA and 23 unexposed controls. We found statistically significant increases in the frequencies of monosomy, trisomy, tetrasomy and SCAs of multiple chromosomes in exposed workers compared with controls, with particularly notable effects for monosomy 1 [P = 6.02E-06, incidence rate ratio (IRR) = 2.31], monosomy 5 (P = 9.01E-06; IRR = 2.24), monosomy 7 (P = 1.57E-05; IRR = 2.17), trisomy 5 (P = 1.98E-05; IRR = 3.40) and SCAs of chromosome 5 (P = 0.024; IRR = 4.15). The detection of increased levels of monosomy 7 and SCAs of chromosome 5 is particularly relevant as they are frequently observed in acute myeloid leukemia. Our findings provide further evidence that leukemia-related cytogenetic changes can occur in the circulating myeloid progenitor cells of healthy workers exposed to FA, which may be a potential mechanism underlying FA-induced leukemogenesis.

Indexed as

AneuploidyAdultCase-Control StudiesCells, CulturedChromosomes, HumanCross-Sectional StudiesDisinfectantsFemaleFollow-Up StudiesFormaldehydeHumansIn Situ Hybridization, FluorescenceMaleMyeloid Progenitor CellsOccupational ExposurePrognosisDisinfectantsFormaldehyde

Identifiers

PMID25391402
PMCPMC4291049
OpenAlexW2326593620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.