ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2014
Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner.European journal of nutrition · 2026Article
- Synthetic microbial community improves chicken intestinal homeostasis and provokes anti-Salmonella immunity mediated by segmented filamentous bacteria.The ISME journal · 2025Article
- Mucosal vaccination in a murine gnotobiotic model ofInfection and immunity · 2024Article
- Review of yeast culture concerning the interactions between gut microbiota and young ruminant animals.Frontiers in veterinary science · 2024Review
- Bacteriophages allow selective depletion of gut bacteria to produce a targeted-bacterium-depleted mouse model.Cell reports methods · 2022Article
- Methods for Establishment and Maintenance of Germ-Free Rat Models.Frontiers in microbiology · 2020Article
- Bioinformatics Analysis of Gut Microbiota and CNS Transcriptome in Virus-Induced Acute Myelitis and Chronic Inflammatory Demyelination; Potential Association of Distinct Bacteria With CNS IgA Upregulation.Frontiers in immunology · 2020Article
- Pathogenetic Impact of Bacterial-Fungal Interactions.Microorganisms · 2019Review
- A potential role for the gut microbiome in substance use disorders.Psychopharmacology · 2019Review
- Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.Molecular ecology · 2017Article
- Gnotobiotic mouse model's contribution to understanding host-pathogen interactions.Cellular and molecular life sciences : CMLS · 2016Review
- Gnotobiotic Rodents: An In Vivo Model for the Study of Microbe-Microbe Interactions.Frontiers in microbiology · 2016Review
- Selective Manipulation of the Gut Microbiota Improves Immune Status in Vertebrates.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbiosis between intestinal microbiota and the host animal plays an important role in the homeostasis of host physiology. Since the first production of germ-free rodents in 1945, it has become increasingly clear that the intestinal immune system and the biochemical characteristics of epithelial cells differ greatly between conventional and germ-free rodents. However, questions remain about the types of microbes involved and the precise mechanism by which these microbes affect the host physiology. Here, we review experiments designed to answer these questions with the use of gnotobiotic mice. We have determined suitable biochemical and immunological markers for monitoring microbial effects in these mice. Using these markers, we have found clear differences in epithelial cell glycolipid biosynthesis and intraepithelial lymphocyte dynamics between germ-free and conventional mice. Furthermore, we have identified a key microbe that activates the mucosal immune system in the small intestine. This indigenous bacteria, called segmented filamentous bacteria, is a key symbiont in the host-microbiota interplay, including Th17 cell-inducing activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.