ArticleNeurology2014
Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity.
Article in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine learning applied to epilepsy: bibliometric and visual analysis from 2004 to 2023.Frontiers in neurology · 2024Pooled it
- Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes.Frontiers in neuroimaging · 2024Pooled it
- Intrinsic and extrinsic connectivity of the seizure onset zone at rest and during stimulation.medRxiv : the preprint server for health sciences · 2026Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- Resting-state functional MRI in pediatric epilepsy: a narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.Frontiers in network physiology · 2025Article
- Spatio-temporal independent component classification for localization of seizure onset zone.Frontiers in neurology · 2025Article
- Pre- and post-therapy functional MRI connectivity in severe acute brain injury with suppression of consciousness: a comparative analysis to epilepsy features.Frontiers in neuroimaging · 2024Article
- T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Autism spectrum disorder-specific changes in white matter connectome edge density based on functionally defined nodes.Frontiers in neuroscience · 2023Article
- Functional and effective connectivity analysis of drug-resistant epilepsy: a resting-state fMRI analysis.Frontiers in neuroscience · 2023Article
- The expert's knowledge combined with AI outperforms AI alone in seizure onset zone localization using resting state fMRI.Frontiers in neurology · 2023Article
- Article
- Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- An integrative prediction algorithm of drug-refractory epilepsy based on combined clinical-EEG functional connectivity features.Journal of neurology · 2022Article
- Common functional connectivity alterations in focal epilepsies identified by machine learning.Epilepsia · 2022Article
- An action-concept processing advantage in a patient with a double motor cortex.Brain and cognition · 2022Article
- Automated seizure onset zone locator from resting-state functional MRI in drug-resistant epilepsy.Frontiers in neuroimaging · 2022Article
- Individual localization value of resting-state fMRI in epilepsy presurgical evaluation: A combined study with stereo-EEG.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
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Authors and funding
10 authors.
Funding
Abstract
objectiveThe purpose of this study was to investigate functional connectivity (FC) changes in epileptogenic networks in intractable partial epilepsy obtained from resting-state fMRI by using intrinsic connectivity contrast (ICC), a voxel-based network measure of degree that reflects the number of connections to each voxel.
methodsWe measured differences between intrahemispheric- and interhemispheric-ICC (ICCintra-inter) that could reveal localized connectivity abnormalities in epileptogenic zones while more global network changes would be eliminated when subtracting these values. The ICCintra-inter map was compared with the seizure onset zone (SOZ) based on intracranial EEG (icEEG) recordings in 29 patients with at least 1 year of postsurgical follow-up. Two independent reviewers blindly interpreted the icEEG and fMRI data, and the concordance rates were compared for various clinical factors.
resultsConcordance between the icEEG SOZ and ICCintra-inter map was observed in 72.4% (21/29) of the patients, which was higher in patients with good surgical outcome, especially in those patients with temporal lobe epilepsy (TLE) or lateral temporal seizure localization. Concordance was also better in the extratemporal lobe epilepsy than the TLE group. In 85.7% (18/21) of the cases, the ICCintra-inter values were negative in the SOZ, indicating decreased FC within the epileptic hemisphere relative to between hemispheres.
conclusionsAssessing alterations in FC using fMRI-ICC map can help localize the SOZ, which has potential as a noninvasive presurgical diagnostic tool to improve surgical outcome. In addition, the method reveals that, in focal epilepsy, both intrahemispheric- and interhemispheric-FC may be altered, in the presence of both regional as well as global network abnormalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.