Evidence map›Paper›PMID 25391153›Full record

ArticlePloS one2014

An odorant-binding protein is abundantly expressed in the nose and in the seminal fluid of the rabbit.

Rosa Mastrogiacomo, Chiara D'Ambrosio, Alberto Niccolini, Andrea Serra, Angelo Gazzano, Andrea Scaloni, Paolo Pelosi

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lipocalins in Arthropod Chemical Communication.Genome biology and evolution · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rosa MastrogiacomoDepartment of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.
Chiara D'AmbrosioProteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, Napoli, Italy.
Alberto NiccoliniDepartment of Veterinary Sciences, University of Pisa, Pisa, Italy.
Andrea SerraDepartment of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.
Angelo GazzanoDepartment of Veterinary Sciences, University of Pisa, Pisa, Italy.
Andrea ScaloniProteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, Napoli, Italy.
Paolo PelosiDepartment of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.
University of Pisa · ITIstituto per il Sistema Produzione Animale in Ambiente Mediterraneo · ITNational Academies of Sciences, Engineering, and Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have purified an abundant lipocalin from the seminal fluid of the rabbit, which shows significant similarity with the sub-class of pheromone carriers "urinary" and "salivary" and presents an N-terminal sequence identical with that of an odorant-binding protein (rabOBP3) expressed in the nasal tissue of the same species. This protein is synthesised in the prostate and found in the seminal fluid, but not in sperm cells. The same protein is also expressed in the nasal epithelium of both sexes, but is completely absent in female reproductive organs. It presents four cysteines, among which two are arranged to form a disulphide bridge, and is glycosylated. This is the first report of an OBP identified at the protein level in the seminal fluid of a vertebrate species. The protein purified from seminal fluid is bound to some organic chemicals whose structure is currently under investigation. We reasonably speculate that, like urinary and salivary proteins reported in other species of mammals, this lipocalin performs a dual role, as carrier of semiochemicals in the seminal fluid and as detector of chemical signals in the nose.

Indexed as

Amino Acid SequenceAnimalsCloning, MolecularDisulfidesFemaleGlycopeptidesGlycosylationLigandsMaleMolecular Sequence DataNasal MucosaPolymerase Chain ReactionProstateProtein Processing, Post-TranslationalProtein Structure, TertiaryRabbitsDisulfidesGlycopeptidesLigandsodorant-binding proteinReceptors, OdorantTrypsin

Identifiers

PMID25391153
PMCPMC4229146
OpenAlexW2035982652

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.