ArticlePloS one2014
Activation of innate immune-response genes in little brown bats (Myotis lucifugus) infected with the fungus Pseudogymnoascus destructans.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- In Silico Analysis of Possible microRNAs Involved in the Pathogenesis of White-Nose Syndrome inInternational journal of molecular sciences · 2025Article
- Strategies and limitations of the bat immune response toFrontiers in immunology · 2025Review
- Transcriptomic evidence of cytokine storm and sepsis in little brown bats exposed to white-nose syndrome.Conservation physiology · 2025Article
- Impact of putatively beneficial genomic loci on gene expression in little brown bats (Evolutionary applications · 2024Article
- Microbiota diversity and anti-Applied and environmental microbiology · 2024Article
- White-Nose Syndrome Disrupts the Splenic Lipidome of Little Brown Bats (Journal of proteome research · 2023Article
- Transcriptional host-pathogen responses ofVirulence · 2020Article
- Major histocompatibility complex variation is similar in little brown bats before and after white-nose syndrome outbreak.Ecology and evolution · 2020Article
- Selection of viral variants during persistent infection of insectivorous bat cells with Middle East respiratory syndrome coronavirus.Scientific reports · 2020Article
- Article
- White-nose syndrome is associated with increased replication of a naturally persisting coronaviruses in bats.Scientific reports · 2018Article
- Body temperatures of hibernating little brown bats reveal pronounced behavioural activity during deep torpor and suggest a fever response during white-nose syndrome.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Article
- Galleria mellonella as an insect model for P. destructans, the cause of White-nose Syndrome in bats.PloS one · 2018Article
- Profiling the immunome of little brown myotis provides a yardstick for measuring the genetic response to white-nose syndrome.Evolutionary applications · 2017Article
- White-nose syndrome increases torpid metabolic rate and evaporative water loss in hibernating bats.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- The other white-nose syndrome transcriptome: Tolerant and susceptible hosts respond differently to the pathogenEcology and evolution · 2017Article
- Lack of inflammatory gene expression in bats: a unique role for a transcription repressor.Scientific reports · 2017Article
- Secondary metabolite arsenal of an opportunistic pathogenic fungus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Generation and Characterization of Eptesicus fuscus (Big brown bat) kidney cell lines immortalized using the Myotis polyomavirus large T-antigen.Journal of virological methods · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently bats have been associated with the emergence of diseases, both as reservoirs for several new viral diseases in humans and other animals and, in the northern Americas, as hosts for a devastating fungal disease that threatens to drive several bat species to regional extinction. However, despite these catastrophic events little Information is available on bat defences or how they interact with their pathogens. Even less is known about the response of bats to infection during torpor or long-term hibernation. Using tissue samples collected at the termination of an experiment to explore the pathogenesis of White Nose Syndrome in Little Brown Bats, we determined if hibernating bats infected with the fungus Pseudogymnoascus destructans could respond to infection by activating genes responsible for innate immune and stress responses. Lesions due to fungal infection and, in some cases, secondary bacterial infections, were restricted to the skin. However, we were unable to obtain sufficient amounts of RNA from these sites. We therefore examined lungs for response at an epithelial surface not linked to the primary site of infection. We found that bats responded to infection with a significant increase in lungs of transcripts for Cathelicidin (an anti-microbial peptide) as well as the immune modulators tumor necrosis factor alpha and interleukins 10 and 23. In conclusion, hibernating bats can respond to experimental P. destructans infection by activating expression of innate immune response genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.