ArticleBrain connectivity2015
Transcallosal connectivity changes from infancy to late adulthood: an ex vivo diffusion spectrum imaging study of macaque brains.
Article in Brain connectivity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- In-vivo diffusion MRI protocol optimization for the chimpanzee brain and examination of aging effects on the primate optic nerve at 3T.Magnetic resonance imaging · 2021Article
- The association of myelination in the internal capsule with iron deposition in the basal ganglia in macaques: a magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2020Article
- Morphology of the corpus callosum and schizophrenia: A case-control study in Kashan, Iran.Electronic physician · 2017Article
- Developmental Whole Brain White Matter Alterations in Transgenic Huntington's Disease Monkey.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Interhemispheric communication plays a critical role to ensure normal brain functions in cognition and behavior. Since non-human primate (NHP) brains resemble most aspects of the human brain, a thorough knowledge of interhemispheric cortical connectivity changes in NHP brains throughout the developmental and aging periods may provide valuable insights for translational and clinical research. In this study, formalin-fixed rhesus monkey brains aged from 1 to 24 years were utilized to examine transcallosal connectivity changes using diffusion spectrum imaging (DSI). It was found that the transcallosal connectivity for most frontal cortical areas, including dorso- and ventro-lateral prefrontal, premotor, and motor cortices, demonstrated pronounced age-related alterations. However, such a pattern was less obvious in temporal, posterior parietal, and visual cortices. The DSI results reveal the age-related evolution pattern of transcallosal connectivity in various cortical areas of macaque brains from infancy to late adulthood, and may have implications for assessing the functional defects or alterations in the associated cortical areas during brain development and aging in humans.
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Registered trials
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