ReviewFrontiers in cellular and infection microbiology2014
An evolving perspective on the Pseudomonas aeruginosa orphan quorum sensing regulator QscR.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes inJournal of bacteriology · 2026Article
- Regulatory mechanisms of quorum sensing in microbial communities and their potential applications in ruminant livestock production.Journal of advanced research · 2026Review
- Insights into the Mechanisms of Small Molecule-Induced Agonism and Antagonism of a Quorum Sensing Receptor inJournal of the American Chemical Society · 2025Article
- Molecular characterization of virulent genes in Pseudomonas aeruginosa based on componential usage divergence.Scientific reports · 2025Article
- Identification and characterization of LuxR solo homolog PplR in pathogenicFrontiers in cellular and infection microbiology · 2024Article
- Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation inMicrobiology (Reading, England) · 2023Article
- Bacillus Co-culture Inhibits Quorum Sensing in Pseudomonas aeruginosa.Current microbiology · 2023Article
- Small Molecules with Either Receptor-Selective or Pan-Receptor Activity in the Three LuxR-Type Receptors that Regulate Quorum Sensing inACS chemical biology · 2022Article
- Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosaJournal of bacteriology · 2022Article
- Identification of a solo acylhomoserine lactone synthase from the myxobacterium Archangium gephyra.Scientific reports · 2021Article
- LuxR Solos in the Plant EndophyteApplied and environmental microbiology · 2020Article
- Flexibility and Adaptability of Quorum Sensing in Nature.Trends in microbiology · 2020Review
- New Vocabulary for Bacterial Communication.Chembiochem : a European journal of chemical biology · 2020Review
- Unraveling the role of quorum sensing-dependent metabolic homeostasis of the activated methyl cycle in a cooperative population of Burkholderia glumae.Scientific reports · 2019Article
- Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues.Nature communications · 2019Article
- Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands.Molecular microbiology · 2018Article
- Review
- Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Additive Effects of Quorum Sensing Anti-Activators onFrontiers in microbiology · 2017Article
- Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing.Frontiers in microbiology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many Proteobacteria govern responses to changes in cell density by using acyl-homoserine lactone (AHL) quorum-sensing (QS) signaling. Similar to the LuxI-LuxR system described in Vibrio fischeri, a minimal AHL QS circuit comprises a pair of genes, a luxI-type synthase gene encoding an enzyme that synthesizes an AHL and a luxR-type AHL-responsive transcription regulator gene. In most bacteria that utilize AHL QS, cognate luxI and luxR homologs are found in proximity to each other on the chromosome. However, a number of recent reports have identified luxR homologs that are not linked to luxI homologs; in some cases luxR homologs have been identified in bacteria that have no luxI homologs. A luxR homolog without a linked luxI homologs is termed an orphan or solo. One of the first reports of an orphan was on QscR in Pseudomonas aeruginosa. The qscR gene was revealed by whole genome sequencing and has been studied in some detail. P. aeruginosa encodes two AHL synthases and three AHL responsive receptors, LasI-LasR form a cognate synthase-receptor pair as do RhlI-RhlR. QscR lacks a linked synthase and responds to the LasI-generated AHL. QS regulation of gene expression in P. aeruginosa employs multiple signals and occurs in the context of other interconnected regulatory circuits that control diverse physiological functions. QscR affects virulence of P. aeruginosa, and although it shows sensitivity to the LasI-generated AHL, 3-oxo-dodecanoylhomoserine lactone, it's specificity is relaxed compared to LasR and can respond equally well to several AHLs. QscR controls a set of genes that overlaps the set regulated by LasR. QscR is comparatively easy to purify and study in vitro, and has become a model for understanding the biochemistry of LuxR homologs. In fact there is a crystal structure of QscR bound to the LasI-generated AHL. Here, we review the current state of research concerning QscR and highlight recent advances in our understanding of its structure and biochemistry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.