Evidence map›Paper›PMID 25389522›Full record

ReviewFrontiers in cellular and infection microbiology2014

Sibling rivalry: related bacterial small RNAs and their redundant and non-redundant roles.

Clayton C Caswell, Amanda G Oglesby-Sherrouse, Erin R Murphy

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Distribution of prophage-encoded Pas sRNAs across pathogenicbioRxiv : the preprint server for biology · 2026
    Article
  3. Origin and adaptive evolutionary trajectory of the 3' UTR-derived sRNA UhpU in Enterobacteriaceae.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Small RNA RyhB Homologs fromMicroorganisms · 2021
    Article
  11. Article
  12. Article
  13. The sRNA DicF integrates oxygen sensing to enhance enterohemorrhagicProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Article
  15. mSphere · 2018
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Clayton C CaswellDepartment of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, VA-MD Regional College of Veterinary Medicine, Virginia Tech Blacksburg, VA, USA.
Amanda G Oglesby-SherrouseDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD, USA ; Department of Microbiology and Immunology, School of Medicine, University of Maryland Baltimore, MD, USA.
Erin R MurphyDepartment of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine Athens, OH, USA.
Ohio University · USUniversity of Maryland, Baltimore · USVirginia Tech · US

Funding

Form and Function of Tandem Duplicate Small RNA Molecules in Shigella dysenteriaeR15AI103887 · NIAID · OHIO UNIVERSITY ATHENS · PI MURPHY, ERIN R · 2013 to 2013
$446k
Analysis of a Shigella dysenteriae Fe regulated promoterF32GM069312 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI MURPHY, ERIN R · 2003 to 2005
$139k
NIAID NIH HHS 1R15AI103887-01A1NIAID NIH HHS R15 AI103887NIGMS NIH HHS F32 GM069312
6 · The paper itself

Abstract

Small RNA molecules (sRNAs) are now recognized as key regulators controlling bacterial gene expression, as sRNAs provide a quick and efficient means of positively or negatively altering the expression of specific genes. To date, numerous sRNAs have been identified and characterized in a myriad of bacterial species, but more recently, a theme in bacterial sRNAs has emerged: the presence of more than one highly related sRNAs produced by a given bacterium, here termed sibling sRNAs. Sibling sRNAs are those that are highly similar at the nucleotide level, and while it might be expected that sibling sRNAs exert identical regulatory functions on the expression of target genes based on their high degree of relatedness, emerging evidence is demonstrating that this is not always the case. Indeed, there are several examples of bacterial sibling sRNAs with non-redundant regulatory functions, but there are also instances of apparent regulatory redundancy between sibling sRNAs. This review provides a comprehensive overview of the current knowledge of bacterial sibling sRNAs, and also discusses important questions about the significance and evolutionary implications of this emerging class of regulators.

Indexed as

Gene Expression Regulation, BacterialBacteriaEvolution, MolecularGenes, BacterialRNA, BacterialVirulenceRNA, Bacterialbacterial small RNAregulationribo-regulationsibling sRNAsRNA

Identifiers

PMID25389522
PMCPMC4211561
OpenAlexW1983777354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.