ArticleIranian Red Crescent medical journal2014
Effects of wheat germ extract on the severity and systemic symptoms of primary dysmenorrhea: a randomized controlled clinical trial.
Article in Iranian Red Crescent medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Self-management strategies for menstrual cycle symptoms: a systematic review.BMC women's health · 2026Pooled it
- Efficacy of Plant-Derived Therapies for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Phytotherapy research : PTR · 2026Pooled it
- Dietary supplements for dysmenorrhoea.The Cochrane database of systematic reviews · 2016Pooled it
- Trial
- Plants in Menstrual Diseases: A Systematic Study from Italian Folk Medicine on Current Approaches.Plants (Basel, Switzerland) · 2024Review
- Relationship between Religious Coping, Pain Severity, and Childbirth Self-Efficacy in Iranian Primipara Women.Obstetrics and gynecology international · 2022Article
- Effects of a dietary modification intervention on menstrual pain and urinary BPA levels: a single group clinical trial.BMC women's health · 2021Article
- Management of Usr-i-Tamth (Menstrual Pain) in Unani (Greco-Islamic) Medicine.Journal of evidence-based complementary & alternative medicine · 2017Review
- The effect ofAvicenna journal of phytomedicineArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary dysmenorrhea is one of the most common disorders in women and the main cause of absenteeism from work and school.
objectivesConsidering the anti-inflammatory properties of wheat germ, the present study examined the effects of wheat germ extract on the severity and systemic symptoms of primary dysmenorrhea. PATIENTS AND
methodsThis triple-blinded clinical trial was performed on 80 employed women in hospitals affiliated with Hamadan University of Medical Sciences (Hamadan, IR Iran). Subjects were allocated to two groups of 45 patients. Three 400-mg capsules of wheat germ extract or placebo were used daily, between the 16th day of the menstrual cycle to the fifth day of the next menstrual cycle for two consecutive months. Pain intensity was measured by a visual analogue scale thrice a day and a four-point verbal rating scale was employed to assess systemic symptoms.
resultsPain severity decreased only in the wheat germ extract group (P < 0.001) and there was no statistically significant change in the placebo group. In the wheat germ extract group, the pain severity decreased from 4.701 at baseline to 1.120 at the second cycle. The reduction in total scores of systemic symptoms of dysmenorrhea was statistically significant only in the wheat germ extract group (P < 0.001) and there was not a statistically significant change in the placebo group. It revealed statistically significant differences in systemic symptoms associated with dysmenorrhea including fatigue, headache, and mood swings in experimental group.
conclusionsWheat germ extract seems to be an effective treatment for dysmenorrhea and its systemic symptoms, probably because of its anti-inflammatory effects.
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