Evidence map›Paper›PMID 25389451›Full record

ArticleTranslational oncology2014

NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures.

Rivka Colen, Ian Foster, Robert Gatenby, Mary Ellen Giger, Robert Gillies, David Gutman, Matthew Heller, Rajan Jain, Anant Madabhushi, Subha Madhavan and 6 more

Abstract read
In one paragraph

Article in Translational oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Review
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  11. Review
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  14. PRISM: A Platform for Imaging in Precision Medicine.JCO clinical cancer informatics · 2020
    Article
  15. Article
  16. Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019
    Article
  17. Robust Histopathology Image Analysis: to Label or to Synthesize?Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rivka ColenMD Anderson Cancer Center, 1400 Pressler Unit: 1482, Houston, TX 77030.
Ian FosterComputation Institute, University of Chicago, 5735 S. Ellis Avenue, Chicago, IL 60637.
Robert GatenbyMoffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
Mary Ellen GigerUniversity of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637.
Robert GilliesMoffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
David GutmanEmory University School of Medicine, 36 Eagle row, 5th Floor South, Atlanta, GA 30322.
Matthew HellerUniversity of Pittsburgh Medical Center, Department of Radiology, 200 Lothrop St., Pittsburgh, PA 15213.
Rajan JainNYU Langone Medical Center, 550 1st Ave, New York, NY 10016 USA.
Anant MadabhushiCase Western Reserve University, 2071 Martin Luther King Jr. Drive, Cleveland, OH 44106-7207.
Subha MadhavanGeorgetown University Medical Center, Suite 2115 Wisconsin Ave, NW, Washington, DC 20057.
Sandy NapelDepartment of Radiology, Stanford University, Stanford, CA 94305.
Arvind RaoMD Anderson Cancer Center, 1400 Pressler Unit: 1482, Houston, TX 77030.
Joel SaltzDepartment of Biomedical Informatics, Stony Brook University, 100 Nicolls Road, Stony Brook, NY 11794.
James TatumHunter Holmes McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249.
Roeland VerhaakMD Anderson Cancer Center, 1400 Pressler Unit: 1482, Houston, TX 77030.
Gary WhitmanMD Anderson Cancer Center, 1515 Holcombe Blvd, #1350, Houston, TX 77030.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Tools for Linking and Mining image and Genomic Data in Non-Small Cell Lung CancerR01CA160251 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., PLEVRITIS, SYLVIA KATINA · 2011 to 2015
$2.9M
Histologic image-based aggressiveness prediction in p16+ oropharyngeal carcinomaR21CA179327 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MADABHUSHI, ANANT · 2014 to 2015
$389k
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA160251NCI NIH HHS R21 CA179327
6 · The paper itself

Abstract

The National Cancer Institute (NCI) Cancer Imaging Program organized two related workshops on June 26-27, 2013, entitled "Correlating Imaging Phenotypes with Genomics Signatures Research" and "Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems." The first workshop focused on clinical and scientific requirements, exploring our knowledge of phenotypic characteristics of cancer biological properties to determine whether the field is sufficiently advanced to correlate with imaging phenotypes that underpin genomics and clinical outcomes, and exploring new scientific methods to extract phenotypic features from medical images and relate them to genomics analyses. The second workshop focused on computational methods that explore informatics and computational requirements to extract phenotypic features from medical images and relate them to genomics analyses and improve the accessibility and speed of dissemination of existing NIH resources. These workshops linked clinical and scientific requirements of currently known phenotypic and genotypic cancer biology characteristics with imaging phenotypes that underpin genomics and clinical outcomes. The group generated a set of recommendations to NCI leadership and the research community that encourage and support development of the emerging radiogenomics research field to address short-and longer-term goals in cancer research.

Identifiers

PMID25389451
PMCPMC4225695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.