ReviewFrontiers in genetics2014
How does evolution tune biological noise?
Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs in three ray-finned fishes.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary dynamics under phenotypic uncertainty.bioRxiv : the preprint server for biology · 2026Article
- Live and let die: Lysis time variability and resource limitation shape lytic bacteriophage fitness.PLoS computational biology · 2026Article
- Environmental perturbation increases gene expression variability and unmasks genetic regulation for transcriptional robustness.bioRxiv : the preprint server for biology · 2026Article
- Article
- Evolving a Field: Can Evolutionary Theory Provide What the Study of Human Evolution Requires?American journal of biological anthropology · 2025Review
- The Role of Alternative Splicing in Marine-Freshwater Divergence in Threespine Stickleback.Genome biology and evolution · 2025Article
- Multiscale chromatin dynamics and high entropy in plant iPSC ancestors.Journal of cell science · 2024Article
- Emerging Role of Chimeric RNAs in Cell Plasticity and Adaptive Evolution of Cancer Cells.Cancers · 2021Review
- Article
- Signaling pathways have an inherent need for noise to acquire information.BMC bioinformatics · 2020Article
- Phenotypic diversity of Methylobacterium associated with rice landraces in North-East India.PloS one · 2020Article
- Antibiotic resilience: a necessary concept to complement antibiotic resistance?Proceedings. Biological sciences · 2019Article
- Resolving noise-control conflict by gene duplication.PLoS biology · 2019Article
- Paf1c defects challenge the robustness of flower meristem termination inDevelopment (Cambridge, England) · 2019Article
- The histone variant H2A.Z in gene regulation.Epigenetics & chromatin · 2019Review
- Deciphering noise amplification and reduction in open chemical reaction networks.Journal of the Royal Society, Interface · 2018Article
- Incompatibilities in Mismatch Repair GenesGenetics · 2018Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Part of molecular and phenotypic differences between individual cells, between body parts, or between individuals can result from biological noise. This source of variation is becoming more and more apparent thanks to the recent advances in dynamic imaging and single-cell analysis. Some of these studies showed that the link between genotype and phenotype is not strictly deterministic. Mutations can change various statistical properties of a biochemical reaction, and thereby the probability of a trait outcome. The fact that they can modulate phenotypic noise brings up an intriguing question: how may selection act on these mutations? In this review, we approach this question by first covering the evidence that biological noise is under genetic control and therefore a substrate for evolution. We then sequentially inspect the possibilities of negative, neutral, and positive selection for mutations increasing biological noise. Finally, we hypothesize on the specific case of H2A.Z, which was shown to both buffer phenotypic noise and modulate transcriptional efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.