ArticleFrontiers in microbiology2014
Impact of interspecific interactions on antimicrobial activity among soil bacteria.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed.
- Article
- Antimicrobial resistance varies with warming in active layer soil and permafrost.Scientific reports · 2026Article
- Competition between resident rhizosphere bacteria enhances phytopathogen suppression via emergent antagonism.The ISME journal · 2026Article
- Interspecies interactions among sugarcane-associated bacteria and their impact on plant growth promotion traits.Frontiers in microbiology · 2026Article
- Community matters: stress tolerance and survival ofFrontiers in microbiology · 2026Article
- Biodiversity and Biological Interactions of Actinobacteria Associated with Deep Sea and Intertidal Marine Invertebrates.Marine drugs · 2025Article
- Novel 3D-Printed Replica Plate Device Ensures High-Throughput Antibacterial Screening of Halophilic Bacteria.Marine drugs · 2025Article
- Carbon source diversity shapes bacterial interspecies interactions.The ISME journal · 2025Article
- Strong pairwise interactions do not drive interactions in a plant leaf associated microbial community.ISME communications · 2025Article
- Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use.Current research in parasitology & vector-borne diseases · 2025Review
- Enhancement of production of pathogen-suppressing volatiles using amino acids.Current research in microbial sciences · 2025Article
- Life on a leaf: the epiphyte to pathogen continuum and interplay in the phyllosphere.BMC biology · 2024Review
- Systematic Evaluation of Biotic and Abiotic Factors in Antifungal Microorganism Screening.Microorganisms · 2024Article
- Idiosyncratic invasion trajectories of human bacterial pathogens facing temperature disturbances in soil microbial communities.Scientific reports · 2024Article
- Manipulating the physical distance between cells during soil colonization reveals the importance of biotic interactions in microbial community assembly.Environmental microbiome · 2024Article
- Interaction ofFrontiers in pharmacology · 2024Article
- Plant Growth-Promoting Bacteria of Soil: Designing of Consortia Beneficial for Crop Production.Microorganisms · 2023Review
- High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery.Metabolites · 2023Review
- Article
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Certain bacterial species produce antimicrobial compounds only in the presence of a competing species. However, little is known on the frequency of interaction-mediated induction of antibiotic compound production in natural communities of soil bacteria. Here we developed a high-throughput method to screen for the production of antimicrobial activity by monocultures and pair-wise combinations of 146 phylogenetically different bacteria isolated from similar soil habitats. Growth responses of two human pathogenic model organisms, Escherichia coli WA321 and Staphylococcus aureus 533R4, were used to monitor antimicrobial activity. From all isolates, 33% showed antimicrobial activity only in monoculture and 42% showed activity only when tested in interactions. More bacterial isolates were active against S. aureus than against E. coli. The frequency of interaction-mediated induction of antimicrobial activity was 6% (154 interactions out of 2798) indicating that only a limited set of species combinations showed such activity. The screening revealed also interaction-mediated suppression of antimicrobial activity for 22% of all combinations tested. Whereas all patterns of antimicrobial activity (non-induced production, induced production and suppression) were seen for various bacterial classes, interaction-mediated induction of antimicrobial activity was more frequent for combinations of Flavobacteria and alpha- Proteobacteria. The results of our study give a first indication on the frequency of interference competitive interactions in natural soil bacterial communities which may forms a basis for selection of bacterial groups that are promising for the discovery of novel, cryptic antibiotics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.