ArticleFrontiers in microbiology2014
Characterization and comparative analysis of antibiotic resistance plasmids isolated from a wastewater treatment plant.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Global analysis of the metaplasmidome: ecological drivers and spread of antibiotic resistance genes across ecosystems.Microbiome · 2025Article
- Molecular Epidemiological Characteristics of Carbapenem ResistantInfection and drug resistance · 2024Article
- Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era.Nature reviews. Microbiology · 2024Review
- Conjugative plasmids inhibit extracellular electron transfer inFrontiers in microbiology · 2023Article
- High Frequency of Antibiotic Resistance Genes (ARGs) in the Lerma River Basin, Mexico.International journal of environmental research and public health · 2022Article
- Deciphering the Regulatory Circuits of RA3 Replication Module - Mechanisms of the Copy Number Control.International journal of molecular sciences · 2022Article
- Microbial Community Resilience across Ecosystems and Multiple Disturbances.Microbiology and molecular biology reviews : MMBR · 2021Review
- Solar photon-Fenton process eliminates free plasmid DNA harboring antimicrobial resistance genes from wastewater.Journal of environmental management · 2021Article
- A high prevalence ofMicrobial genomics · 2021Article
- Biosolids as a Source of Antibiotic Resistance Plasmids for Commensal and Pathogenic Bacteria.Frontiers in microbiology · 2021Article
- Characterization of the Plasmidome Encoding Carbapenemase and Mechanisms for Dissemination of Carbapenem-ResistantmSystems · 2020Article
- Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China.Environmental science and pollution research international · 2019Article
- Horizontal Dissemination of Antimicrobial Resistance Determinants in Multiple Salmonella Serotypes following Isolation from the Commercial Swine Operation Environment after Manure Application.Applied and environmental microbiology · 2017Article
- Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa.MicrobiologyOpen · 2016Article
- Diversity and role of plasmids in adaptation of bacteria inhabiting the Lubin copper mine in Poland, an environment rich in heavy metals.Frontiers in microbiology · 2015Article
- The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.Frontiers in microbiology · 2015Article
- Exploring antibiotic resistance genes and metal resistance genes in plasmid metagenomes from wastewater treatment plants.Frontiers in microbiology · 2015Article
- Diversity and Global Distribution of IncL/M Plasmids Enabling Horizontal Dissemination of β-Lactam Resistance Genes among the Enterobacteriaceae.BioMed research international · 2015Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wastewater treatment plant (WWTP) is an environment high in nutrient concentration with diverse bacterial populations and can provide an ideal environment for the proliferation of mobile elements such as plasmids. WWTPs have also been identified as reservoirs for antibiotic resistance genes that are associated with human pathogens. The objectives of this study were to isolate and characterize self-transmissible or mobilizable resistance plasmids associated with effluent from WWTP. An enrichment culture approach designed to capture plasmids conferring resistance to high concentrations of erythromycin was used to capture plasmids from an urban WWTP servicing a population of ca. 210,000. DNA sequencing of the plasmids revealed diversity of plasmids represented by incompatibility groups IncU, col-E, IncFII and IncP-1β. Genes coding resistance to clinically relevant antibiotics (macrolide, tetracycline, beta-lactam, trimethoprim, chloramphenicol, sulphonamide), quaternary ammonium compounds and heavy metals were co-located on these plasmids, often within transposable and integrative mobile elements. Several of the plasmids were self-transmissible or mobilizable and could be maintained in the absence of antibiotic selection. The IncFII plasmid pEFC36a showed the highest degree of sequence identity to plasmid R1 which has been isolated in England more than 50 years ago from a patient suffering from a Salmonella infection. Functional conservation of key regulatory features of this F-like conjugation module were demonstrated by the finding that the conjugation frequency of pEFC36a could be stimulated by the positive regulator of plasmid R1 DNA transfer genes, TraJ.
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