ArticleFrontiers in human neuroscience2014
Brain activation associated with active and passive lower limb stepping.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Characterizing the supraspinal sensorimotor control of walking using MRI-compatible system: a systematic review.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Observational Evidence of the Association Between Handgrip Strength, Hand Dexterity, and Cognitive Performance in Community-Dwelling Older Adults: A Systematic Review.Journal of epidemiology · 2018Pooled it
- Reviewing Clinical Effectiveness of Active Training Strategies of Platform-Based Ankle Rehabilitation Robots.Journal of healthcare engineering · 2018Pooled it
- Effects of exoskeleton rehabilitation robot training on neuroplasticity and lower limb motor function in patients with stroke.BMC neurology · 2025Trial
- Neurophysiological correlates of passive movements are speed- and type-dependent.European journal of applied physiology · 2026Article
- Supplementary Motor Area During Motor Actions in Athletes With Neurological Disorders: Observational Study of Cases and Controls.Brain and behavior · 2026Observational
- Cortical candidates for self-other distinction based on visual and action cues: where do we stand?Brain structure & function · 2026Review
- Reliability of Brain Activity During a Supine Bilateral Leg Press and Association With Concurrent 3D Knee Joint Biomechanics.The European journal of neuroscience · 2025Article
- The laminar pattern of proprioceptive activation in human primary motor cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cerebellar functional connectivity alteration in individuals with lower limb amputation.PloS one · 2025Article
- Mobile neuroimaging: What we have learned about the neural control of human walking, with an emphasis on EEG-based research.Neuroscience and biobehavioral reviews · 2024Review
- Use of functional magnetic resonance imaging to identify cortical loci for lower limb movements and their efficacy for individuals after stroke.Journal of neuroengineering and rehabilitation · 2024Article
- The effects of sports-related concussion history on female adolescent brain activity and connectivity for bilateral lower extremity knee motor control.Psychophysiology · 2023Article
- Lower extremity Interlimb coordination associated brain activity in young female athletes: A biomechanically instrumented neuroimaging study.Psychophysiology · 2023Article
- Article
- Brain Response to a Knee Proprioception Task Among Persons With Anterior Cruciate Ligament Reconstruction and Controls.Frontiers in human neuroscience · 2022Article
- Design, Manufacturing, and Control of a Pneumatic-Driven Passive Robotic Gait Training System for Muscle-Weakness in a Lower Limb.Sensors (Basel, Switzerland) · 2021Article
- Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Review
- Integrated 3D motion analysis with functional magnetic resonance neuroimaging to identify neural correlates of lower extremity movement.Journal of neuroscience methods · 2021Article
- Differential Theta-Band Signatures of the Anterior Cingulate and Motor Cortices During Seated Locomotor Perturbations.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reports about standardized and repeatable experimental procedures investigating supraspinal activation in patients with gait disorders are scarce in current neuro-imaging literature. Well-designed and executed tasks are important to gain insight into the effects of gait-rehabilitation on sensorimotor centers of the brain. The present study aims to demonstrate the feasibility of a novel imaging paradigm, combining the magnetic resonance (MR)-compatible stepping robot (MARCOS) with sparse sampling functional magnetic resonance imaging (fMRI) to measure task-related BOLD signal changes and to delineate the supraspinal contribution specific to active and passive stepping. Twenty-four healthy participants underwent fMRI during active and passive, periodic, bilateral, multi-joint, lower limb flexion and extension akin to human gait. Active and passive stepping engaged several cortical and subcortical areas of the sensorimotor network, with higher relative activation of those areas during active movement. Our results indicate that the combination of MARCOS and sparse sampling fMRI is feasible for the detection of lower limb motor related supraspinal activation. Activation of the anterior cingulate and medial frontal areas suggests motor response inhibition during passive movement in healthy participants. Our results are of relevance for understanding the neural mechanisms underlying gait in the healthy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.