ArticleFrontiers in behavioral neuroscience2014
Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others.Nature communications · 2023Article
- Everything is connected: Inference and attractors in delusions.Schizophrenia research · 2022Article
- Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour.Journal of psychopharmacology (Oxford, England) · 2021Article
- The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function.Behavior research methods · 2021Article
- Time elapsed between choices in a probabilistic task correlates with repeating the same decision.The European journal of neuroscience · 2021Article
- Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways.Nature communications · 2018Article
- Pharmacological Blockade of Adenosine AFrontiers in pharmacology · 2018Article
- To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.Frontiers in integrative neuroscience · 2018Article
- Dissociating Attention and Eye Movements in a Quantitative Analysis of Attention Allocation.Frontiers in psychology · 2017Article
- Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown.Scientific reports · 2016Article
- Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neuronal activity in dorsomedial and dorsolateral striatum under the requirement for temporal credit assignment.Scientific reports · 2016Article
- Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.Frontiers in neural circuits · 2016Article
- Injection of a dopamine type 2 receptor antagonist into the dorsal striatum disrupts choices driven by previous outcomes, but not perceptual inference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas D1R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment.
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