ArticleNucleic acids research2014
Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Modular Scaffold Crystals for Programmable Installation and Structural Observation of DNA-Binding Proteins.bioRxiv : the preprint server for biology · 2026Article
- Barium Concentration-Dependent Anomalous Electrophoresis of Synthetic DNA Motifs.ACS applied bio materials · 2024Article
- Self-Assembly of DNA Nanostructures in Different Cations.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Insight into Tetramolecular DNA G-Quadruplexes Associated with ALS and FTLD: Cation Interactions and Formation of Higher-Ordered Structure.International journal of molecular sciences · 2023Article
- Self-assembly of DNA nanostructures in different cations.bioRxiv : the preprint server for biology · 2023Article
- Non-G Base Tetrads.Molecules (Basel, Switzerland) · 2022Review
- How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence.Nucleic acids research · 2021Article
- InterMetalDB: A Database and Browser of Intermolecular Metal Binding Sites in Macromolecules with Structural Information.Journal of proteome research · 2021Article
- A DNA G-quadruplex/i-motif hybrid.Nucleic acids research · 2019Article
- Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.Nature communications · 2019Article
- High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads.Nucleic acids research · 2018Article
- NMR structure of a G-quadruplex formed by four d(G4C2) repeats: insights into structural polymorphism.Nucleic acids research · 2018Article
- Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge.Nucleic acids research · 2018Article
- Structural and Dynamical Characterization of DNA and RNA Quadruplexes Obtained from the GGGGCC and GGGCCT Hexanucleotide Repeats Associated with C9FTD/ALS and SCA36 Diseases.ACS chemical neuroscience · 2018Article
- A highly Sensitive Turn-on Fluorescent Sensor for BaJournal of fluorescence · 2017Article
- Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Structure, Properties, and Biological Relevance of the DNA and RNA G-Quadruplexes: Overview 50 Years after Their Discovery.Biochemistry. Biokhimiia · 2016Article
- Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation.Nucleic acids research · 2015Article
- An intercalation-locked parallel-stranded DNA tetraplex.Nucleic acids research · 2015Article
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4 authors.
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Abstract
We have determined the 1.50 Å crystal structure of the DNA decamer, d(CCA(CNV)KGCGTGG) ((CNV)K, 3-cyanovinylcarbazole), which forms a G-quadruplex structure in the presence of Ba(2+). The structure contains several unique features including a bulged nucleotide and the first crystal structure observation of a C-tetrad. The structure reveals that water molecules mediate contacts between the divalent cations and the C-tetrad, allowing Ba(2+) ions to occupy adjacent steps in the central ion channel. One ordered Mg(2+) facilitates 3'-3' stacking of two quadruplexes in the asymmetric unit, while the bulged nucleotide mediates crystal contacts. Despite the high diffraction limit, the first four nucleotides including the (CNV)K nucleoside are disordered though they are still involved in crystal packing. This work suggests that the bulky hydrophobic groups may locally influence the formation of non-Watson-Crick structures from otherwise complementary sequences. These observations lead to the intriguing possibility that certain types of DNA damage may act as modulators of G-quadruplex formation.
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