ArticleToxicological sciences : an official journal of the Society of Toxicology2015
Biological dose response to PM2.5: effect of particle extraction method on platelet and lung responses.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980-2020.Heliyon · 2022Review
- Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation.Particle and fibre toxicology · 2021Article
- Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2021Article
- In vivo and in vitro inflammatory responses to fine particulate matter (PMToxicology letters · 2020Article
- Multiomics of World Trade Center Particulate Matter-induced Persistent Airway Hyperreactivity. Role of Receptor for Advanced Glycation End Products.American journal of respiratory cell and molecular biology · 2020Article
- Carcinogenic risks and chemical composition of particulate matter recovered by two methods: wet and dry extraction.Environmental monitoring and assessment · 2020Article
- Combining Data from Multiple Sources to Evaluate Spatial Variations in the Economic Costs of PMInternational journal of environmental research and public health · 2019Article
- Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice.International journal of environmental research and public health · 2019Article
- PMEnvironmental science & technology · 2019Article
- In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice.Environmental pollution (Barking, Essex : 1987) · 2018Article
- Spatiotemporal Assessment of PMInternational journal of environmental research and public health · 2018Article
- Tubeimoside I attenuates inflammation and oxidative damage in a mice model of PMExperimental and therapeutic medicine · 2018Article
- Fine particulate matter (PMJournal of toxicology and environmental health. Part A · 2017Article
- Association of IL-6 with PMWater, air, and soil pollution · 2017Article
- Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells.Journal of cellular and molecular medicine · 2016Review
- Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice.Particle and fibre toxicology · 2016Article
- Characterization of ambient and extracted PM2.5 collected on filters for toxicology applications.Inhalation toxicology · 2015Article
- Pulmonary and systemic toxicity in rats following inhalation exposure of 3-D printer emissions from acrylonitrile butadiene styrene (ABS) filament.Inhalation toxicologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Particulate matter (PM) exposure contributes to respiratory diseases and cardiopulmonary mortality. PM toxicity is related to sources and composition, such as abundance of polycyclic aromatic hydrocarbons (PAHs). We exposed adult male BALB/c mice, via oropharyngeal aspiration, to a range of doses of PM2.5 collected during the winter in downtown Sacramento near a major freeway interchange (SacPM). Two preparation methods (spin-down and multi-solvent extraction) were tested to remove particles from collection filters. Three doses were analyzed 24 h after treatment for (1) leukocytes and total protein in bronchoalveolar lavage fluid (BALF), (2) airway-specific and whole lobe expression of PAH-sensitive genes (CYP1B1 and CYP1A1) and IL-1 b, (3) lung histology, and (4) platelet function. Both extraction methods stimulated biological responses, but the spin-down method was more robust at producing IL-1 b and CYP1B1 gene responses and the multi-solvent extraction induced whole lung CYP1A1. Neutrophils in the BALF were increased 5- to 10-fold at the mid and high dose for both preparations. Histopathology scores indicated dose-dependent responses and increased pathology associated with spin-down-derived PM exposure. In microdissected airways, spin-down PM increased CYP1B1 gene expression significantly, but multi-solvent extracted PM did not. Platelet responses to the physiological agonist thrombin were approximately twice as potent in the spin-down preparation as in the multi-solvent extract. We conclude (1) the method of filter extraction can influence the degree of biological response, (2) for SacPM the minimal effective dose is 27.5-50 µg based on neutrophil recruitment, and (3) P450s are upregulated differently in airways and lung parenchyma in response to PAH-containing PM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.