Trial reportThorax2014
SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis.
Trial report in Thorax, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypertonic Saline in Acute Bronchiolitis: Randomised Controlled Trial and Economic Evaluation
The Effectiveness of Nebulized 3% Hypertonic Saline With Salbutamol in Acute Bronchiolitis in Hospitalised Children- a Randomized Clinical Trial
Who cites it
28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Working group summary of the 2023 full update of the Finnish national guidelines for paediatric lower respiratory tract infections.Acta paediatrica (Oslo, Norway : 1992) · 2025Guideline
- Pooled it
- Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials.BMC pediatrics · 2020Pooled it
- The cost-effectiveness of hypertonic saline inhalations for infant bronchiolitis: a decision analysis.World journal of pediatrics : WJP · 2018Pooled it
- Nebulised hypertonic saline solution for acute bronchiolitis in infants.The Cochrane database of systematic reviews · 2017Pooled it
- Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis.BMC pulmonary medicine · 2015Pooled it
- Nebulized hypertonic saline 3% for 1 versus 3 days in hospitalized bronchiolitis: a blinded non-inferiority randomized controlled trial.BMC pediatrics · 2019Trial
- Prospective Multicentre Study on the Epidemiology and Current Therapeutic Management of Severe Bronchiolitis in Spain.BioMed research international · 2017Trial
- Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial.PloS one · 2015Trial
- Efficacies of different treatment strategies for infants hospitalized with acute bronchiolitis.Clinical and experimental pediatrics · 2024Article
- Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome.Genes and immunity · 2023Article
- Twenty-one-year follow-up revealed guideline-concordant and non-concordant trends in intensive care of bronchiolitis.European journal of pediatrics · 2023Article
- Nebulised hypertonic saline solution for acute bronchiolitis in infants.The Cochrane database of systematic reviews · 2023Review
- UPDATE - 2022 Italian guidelines on the management of bronchiolitis in infants.Italian journal of pediatrics · 2023Review
- Effects of Different Inhalation Therapy on Ventilator-Associated Pneumonia in Ventilated COVID-19 Patients: A Randomized Controlled Trial.Microorganisms · 2022Article
- The Unmet Needs in Atopic Dermatitis Control in Latin America: A Multidisciplinary Expert Perspective.Dermatology and therapy · 2021Review
- Article
- Efficacy of 3% hypertonic saline in bronchiolitis: A meta-analysis.Experimental and therapeutic medicine · 2019Article
- The change in management of bronchiolitis in the intensive care unit between 2000 and 2015.European journal of pediatrics · 2018Article
- Viral bronchiolitis.Lancet (London, England) · 2017Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
aimAcute bronchiolitis is the commonest cause for hospitalisation in infancy. Supportive care remains the cornerstone of current management and no other therapy has been shown to influence the course of the disease. It has been suggested that adding nebulised hypertonic saline to usual care may shorten the duration of hospitalisation. To determine whether hypertonic saline does have beneficial effects we undertook an open, multi-centre parallel-group, pragmatic RCT in ten UK hospitals.
methodsInfants admitted to hospital with a clinical diagnosis of acute bronchiolitis and requiring oxygen therapy were randomised to receive usual care alone or nebulised 3% hypertonic saline (HS) administered 6-hourly. Randomisation was within 4 h of admission. The primary outcome was time to being assessed as 'fit' for discharge with secondary outcomes including time to discharge, incidence of adverse events together with follow up to 28 days assessing patient centred health related outcomes.
resultsA total of 317 infants were recruited to the study. 158 infants were randomised to HS (141 analysed) and 159 to standard care (149 analysed). There was no difference between the two arms in time to being declared fit for discharge (hazard ratio: 0-95, 95% CI: 0.75-1.20) nor to actual discharge (hazard ratio: 0.97, 95% CI: 0.76-1.23). There was no difference in adverse events. One infant in the HS group developed bradycardia with desaturation.
conclusionThis study does not support the use of nebulised HS in the treatment of acute bronchiolitis over usual care with minimal handlings. CLINICALTRIALSGOV REGISTRATION NUMBER: NCT01469845.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.