ArticleJournal of biomedical materials research. Part B, Applied biomaterials2015
Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Biomimetic Surface Engineering Strategies for Enhanced Osseointegration and Peri-Implant Bone Regeneration: A Systematic Review.Biomimetics (Basel, Switzerland) · 2026Review
- Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition.Frontiers in bioengineering and biotechnology · 2025Article
- Biomimetic Coatings in Implant Dentistry: A Quick Update.Journal of functional biomaterials · 2023Review
- Study on the Possibilities of Developing Cementitious or Geopolymer Composite Materials with Specific Performances by Exploiting the Photocatalytic Properties of TiOMaterials (Basel, Switzerland) · 2023Review
- Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation.Pharmaceutics · 2022Review
- Antibacterial metals and alloys for potential biomedical implants.Bioactive materials · 2021Review
- The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation.Journal of clinical medicine · 2021Review
- Influence of TiOMaterials (Basel, Switzerland) · 2021Article
- Review
- Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials.Materials (Basel, Switzerland) · 2020Review
- The Impact of Incorporating Antimicrobials into Implant Surfaces.Journal of dental research · 2018Review
- Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis.Antimicrobial agents and chemotherapy · 2017Article
- Microbial adhesion on novel yttria-stabilized tetragonal zirconia (Y-TZP) implant surfaces with nitrogen-doped hydrogenated amorphous carbon (a-C:H:N) coatings.Clinical oral investigations · 2016Article
- Anti-infective Surface Coatings: Design and Therapeutic Promise against Device-Associated Infections.PLoS pathogens · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
As peri-prosthetic infection is one of the most devastating complications associated with implant placement, we have reasoned that such infection can be largely subverted by development of antibacterial implants. Our previous work demonstrated that covalent coupling of vancomycin to titanium alloy prevented colonization by the Gram-positive pathogens, Staphylococcus aureus and Staphylococcus epidermidis. Some orthopedic devices, including permanent prosthesis anchors, and most dental implants are transcutaneous or transmucosal and can be prone to colonization by Gram-negative pathogens. We report here the successful covalent coupling of the broad-spectrum antibiotic, tetracycline (TET), to titanium surfaces (Ti-TET) to retard Gram-negative colonization. Synthetic progress was followed by changes in water contact angle, while the presence of TET was confirmed by immunofluorescence. Ti-TET actively prevented colonization in the presence of bathing Escherichia coli, both by fluorescence microscopy and direct counting. Finally, the Ti-TET surface supported osteoblastic cell adhesion and proliferation over a 72-h period. Thus, this new surface offers a powerful means to protect transcutaneous implants from adhesion of Gram-negative pathogens, decreasing the need for replacement of this hardware.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.