ArticleMucosal immunology2015
Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation.
Article in Mucosal immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Trial
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- Th2 Cytokines Reshape the Transcriptome: Insights from a Canine Organoid Model of Atopic Dermatitis.International journal of molecular sciences · 2026Article
- Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis.Allergy · 2026Article
- Recurrent Osteomyelitis in a Paediatric Patient with a NovelChildren (Basel, Switzerland) · 2025Article
- Inhibition of FABP4 Ameliorates IL-13-Induced Inflammatory Response and Barrier Dysfunction in Nasal Mucosal Epithelial Cells through the Regulation of Ferroptosis.Cell biochemistry and biophysics · 2025Article
- A novel treatment strategy with hyperbaric oxygen of chronic osteomyelitis and pseudoarthrosis in a child with congenital hereditary sensory and autonomic neuropathy type 4 congenital insensitivity to pain with anhidrosis syndrome: a case report.Journal of medical case reports · 2025Article
- IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone.Frontiers in immunology · 2025Article
- Changes in Gene Expression Related to Atopic Dermatitis in Mothers and Infants Following VOC Exposure.International journal of molecular sciences · 2024Article
- CTPAD: an interactive web application for comprehensive transcriptomic profiling in allergic diseases.Journal of translational medicine · 2024Article
- A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome.The Journal of allergy and clinical immunology · 2024Article
- The role of deacetylase SIRT1 in allergic diseases.Frontiers in immunology · 2024Review
- HDAC4 depletion ameliorates IL-13-triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF-κB signaling.Immunity, inflammation and disease · 2022Article
- DNA methylation biomarkers in asthma and rhinitis: Are we there yet?Clinical and translational allergy · 2022Review
- Construction and analysis for dys-regulated lncRNAs and mRNAs in LPS-induced porcine PBMCs.Innate immunity · 2021Article
- COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum.Journal of cellular and molecular medicine · 2021Article
- Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT LigandGenetics · 2020Article
- Nasal DNA methylation profiling of asthma and rhinitis.The Journal of allergy and clinical immunology · 2020Article
- Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study.The Lancet. Respiratory medicine · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Although interleukin (IL)-13 and neurotrophins are functionally important for the pathogenesis of immune responses, the interaction of these pathways has not been explored. Herein, by interrogating IL-13-induced responses in human epithelial cells we show that neurotrophic tyrosine kinase receptor, type 1 (NTRK1), a cognate, high-affinity receptor for nerve growth factor (NGF), is an early transcriptional IL-13 target. Induction of NTRK1 was accompanied by accumulation of activating epigenetic marks in the promoter; transcriptional and epigenetic changes were signal transducer and activator of transcription 6 dependent. Using eosinophilic esophagitis as a model for human allergic inflammation, we found that NTRK1 was increased in inflamed tissue and dynamically expressed as a function of disease activity and that the downstream mediator of NTRK1 signaling early growth response 1 protein was elevated in allergic inflammatory tissue compared with control tissue. Unlike NTRK1, its ligand NGF was constitutively expressed in control and disease states, indicating that IL-13-stimulated NTRK1 induction is a limiting factor in pathway activation. In epithelial cells, NGF and IL-13 synergistically induced several target genes, including chemokine (C-C motif) ligand 26 (eotaxin-3). In summary, we have demonstrated that IL-13 confers epithelial cell responsiveness to NGF by regulating NTRK1 levels by a transcriptional and epigenetic mechanism and that this process likely contributes to allergic inflammation.
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