Evidence map›Paper›PMID 25388957›Full record

ArticleLeukemia2015

Clonal origins of ETV6-RUNX1⁺ acute lymphoblastic leukemia: studies in monozygotic twins.

D Alpar, D Wren, L Ermini, M B Mansur, F W van Delft, C M Bateman, I Titley, L Kearney, T Szczepanski, D Gonzalez and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Risk of leukemia in twins.Haematologica · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Biomedicines · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. The Second Oncogenic Hit Determines the Cell Fate ofFrontiers in cell and developmental biology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

D Alpar1] Centre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK [2] Department of Pathology, University of Pecs, Pecs, Hungary.
D WrenHaemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research-London, London, UK.
L ErminiCentre for Geogenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen K, Denmark.
M B Mansur1] Centre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK [2] Pediatric Hematology-Oncology Program, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
F W van DelftCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
C M BatemanCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
I TitleyCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
L KearneyCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
T SzczepanskiDepartment of Pediatric Hematology and Oncology, Zabrze, Medical University of Silesia, Katowice, Poland.
D GonzalezHaemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research-London, London, UK.
A M FordCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
N E PotterCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
M GreavesCentre for Evolution and Cancer, The Institute of Cancer Research-London, London, UK.
Institute of Cancer Research · GBMedical University of Silesia · PLNatural History Museum Aarhus · DK

Funding

Wellcome Trust 105104Wellcome Trust 105104/Z/14/Z
6 · The paper itself

Abstract

Studies on twins with concordant acute lymphoblastic leukemia (ALL) have revealed that ETV6-RUNX1 gene fusion is a common, prenatal genetic event with other driver aberrations occurring subclonally and probably postnatally. The fetal cell type that is transformed by ETV6-RUNX1 is not identified by such studies or by the analysis of early B-cell lineage phenotype of derived progeny. Ongoing, clonal immunoglobulin (IG) and cross-lineage T-cell receptor (TCR) gene rearrangements are features of B-cell precursor leukemia and commence at the pro-B-cell stage of normal B-cell lineage development. We reasoned that shared clonal rearrangements of IG or TCR genes by concordant ALL in twins would be informative about the fetal cell type in which clonal advantage is elicited by ETV6-RUNX1. Five pairs of twins were analyzed for all varieties of IG and TCR gene rearrangements. All pairs showed identical incomplete or complete variable-diversity-joining junctions coupled with substantial, subclonal and divergent rearrangements. This pattern was endorsed by single-cell genetic scrutiny in one twin pair. Our data suggest that the pre-leukemic initiating function of ETV6-RUNX1 fusion is associated with clonal expansion early in the fetal B-cell lineage.

Indexed as

Gene Expression Regulation, LeukemicB-LymphocytesCell LineageClone CellsCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinFemaleFetusGene Rearrangement, T-LymphocyteHumansMaleOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaPrecursor Cells, B-LymphoidReceptors, FcTime FactorsCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinOncogene Proteins, FusionReceptors, FcTEL-AML1 fusion protein

Identifiers

PMID25388957
OpenAlexW2028128777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.