Evidence map›Paper›PMID 25388852›Full record

ArticleEpidemiology and infection2015

Evaluation of neonatal Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in HBV intrauterine transmission susceptibility.

Y Gao, J Guo, F Zhang, Z Guo, L R Zhang, T Wang, B Wang, S Y Feng, S P Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis.Journal of clinical and translational hepatology · 2017
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Y GaoSchool of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
J GuoDepartment of Epidemiology,School of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
F ZhangDepartment of Epidemiology,School of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
Z GuoDepartment of Epidemiology,School of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
L R ZhangDepartment of Epidemiology,School of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
T WangDepartment of Epidemiology,School of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
B WangObstetrics and Gynaecology Department,the Third People's Hospital of Taiyuan City,Taiyuan,Shanxi,P.R. China.
S Y FengObstetrics and Gynaecology Department,the Third People's Hospital of Taiyuan City,Taiyuan,Shanxi,P.R. China.
S P WangDepartment of Epidemiology,School of Public Health, Shanxi Medical University,Taiyuan,Shanxi,P.R. China.
Shanxi Medical University · CNFourth People's Hospital of Taiyuan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate whether single nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 3 and 9 affect the susceptibility of hepatitis B virus (HBV) intrauterine transmission, we genotyped 399 neonates for TLR3 (c.1377C/T) [rs3775290] and TLR9 (G2848A) [rs352140] using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A femoral venous blood sample was obtained from these subjects. Hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) were measured using chemiluminescence immunoassay kits and hepatitis B virus DNA (HBV DNA) levels were determined by fluorescence quantitative PCR assay. Our results showed that when adjusting for maternal HBeAg, maternal HBV DNA and mode of delivery, allele 'T' for SNP c.1377C/T was significantly associated with HBV intrauterine transmission susceptibility [adjusted OR (aOR) 0.55, 95% confidence interval (CI) 0.34-0.91, P = 0.020] and the TT genotype decreased the risk of HBV intrauterine transmission (aOR 0.28, 95% CI 0.09-0.91, P = 0.033). Allele 'A' for SNP G2848A was significantly associated with HBV intrauterine transmission susceptibility (aOR 0.62, 95% CI 0.39-1.00, P = 0.048) and the GA genotype protected neonates from HBV intrauterine transmission (aOR 0.45, 95% CI 0.22-0.93, P = 0.031). The TLR3 (c.1377C/T) and TLR9 (G2848A) polymorphisms may be relevant for HBV intrauterine transmission susceptibility, although the reduction in risk to HBV intrauterine transmission is modest and the biological mechanism of the observed association merits further investigation.

Indexed as

Infectious Disease Transmission, VerticalAdultCase-Control StudiesFemaleHepatitis BHepatitis B virusHumansInfant, NewbornMalePolymorphism, Single NucleotideToll-Like Receptor 3Toll-Like Receptor 9Young AdultTLR3 protein, humanTLR9 protein, humanToll-Like Receptor 3Toll-Like Receptor 9HBVintrauterine transmissionpolymorphismsToll-like receptor

Identifiers

PMID25388852
PMCPMC9507260
OpenAlexW2166006345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.