ArticleScientific reports2014
Ion-activated attractive patches as a mechanism for controlled protein interactions.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Proline stabilizes amphiphilic gold nanoparticlesNanoscale horizons · 2025Article
- Continuity of Short-Time Dynamics Crossing the Liquid-Liquid Phase Separation in Charge-Tuned Protein Solutions.The journal of physical chemistry letters · 2024Article
- Liquid-liquid phase separation driven by charge heterogeneity.Communications physics · 2024Article
- Effective interactions and phase behavior of protein solutions in the presence of hexamine cobalt(III) chloride.The European physical journal. E, Soft matter · 2023Article
- Protein Association in Solution: Statistical Mechanical Modeling.Biomolecules · 2023Review
- Ion-bridges and lipids drive aggregation of same-charge nanoparticles on lipid membranes.Nanoscale · 2022Article
- Effect of Temperature on Re-entrant Condensation of Globular Protein in Presence of Tri-valent Ions.Journal of fluorescence · 2022Article
- Impact of Arginine-Phosphate Interactions on the Reentrant Condensation of Disordered Proteins.Biomacromolecules · 2021Article
- Zinc determines dynamical properties and aggregation kinetics of human insulin.Biophysical journal · 2021Article
- Multivalent ions and biomolecules: Attempting a comprehensive perspective.Chemphyschem : a European journal of chemical physics and physical chemistry · 2020Review
- Enhanced protein adsorption upon bulk phase separation.Scientific reports · 2020Article
- Weak Shape Anisotropy Leads to a Nonmonotonic Contribution to Crowding, Impacting Protein Dynamics under Physiologically Relevant Conditions.The journal of physical chemistry. B · 2018Article
- Reentrant Phase Transitions and Non-Equilibrium Dynamics in Membraneless Organelles.Biochemistry · 2018Article
- Article
- Can the propensity of protein crystallization be increased by using systematic screening with metals?Protein science : a publication of the Protein Society · 2017Review
- Review
- The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding.BMC biophysics · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The understanding of protein interactions to control phase and nucleation behavior of protein solutions is an important challenge for soft matter, biological and medical research. Here, we present ion bridges of multivalent cations between proteins as an ion-activated mechanism for patchy interaction that is directly supported by experimental findings in protein crystals. A deep understanding of experimentally observed phenomena in protein solutions--including charge reversal, reentrant condensation, metastable liquid-liquid phase separation, cluster formation and different pathways of crystallization--is gained by an analytic model that directly displays parameter dependencies and physical connections. The direct connection between experiment and theory provides a conceptual framework for future experimental, computational and theoretical research on topics such as rational design of phase behavior and crystallization pathways on the basis of the statistical physics of patchy particles.
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