ArticleMolecular microbiology2015
Specific N-terminal cleavage of ribosomal protein L27 in Staphylococcus aureus and related bacteria.
Article in Molecular microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Analysis of essential genes inJournal of bacteriology · 2025Article
- Cysteine proteases and how YabG fits into clan CD of the MEROPS database.Journal of bacteriology · 2025Review
- Cleavage ofbioRxiv : the preprint server for biology · 2025Article
- Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025Article
- Ribosomal-processing cysteine protease homolog modulatesJournal of bacteriology · 2024Article
- Phage-Related Ribosomal Proteases (Prps): Discovery, Bioinformatics, and Structural Analysis.Antibiotics (Basel, Switzerland) · 2022Article
- Phage-Related Ribosomal Protease (Prp) ofBiochemistry · 2022Article
- A switch from α-helical to β-strand conformation during co-translational protein folding.The EMBO journal · 2022Article
- Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands.Nature communications · 2021Article
- Origins of peptidases.Biochimie · 2019Article
- Molecular Piracy: Redirection of Bacteriophage Capsid Assembly by Mobile Genetic Elements.Viruses · 2019Review
- Synergistic Anti-MRSA Activity of Cationic Nanostructured Lipid Carriers in Combination With Oxacillin for Cutaneous Application.Frontiers in microbiology · 2018Article
- Cleavage and Structural Transitions during Maturation of Staphylococcus aureus Bacteriophage 80α and SaPI1 Capsids.Viruses · 2017Article
- Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus.Molecular microbiology · 2017Article
- Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application.Frontiers in microbiology · 2017Article
- Structure of the 70S ribosome from human pathogen Staphylococcus aureus.Nucleic acids research · 2016Article
- Unknown unknowns: essential genes in quest for function.Microbial biotechnology · 2016Review
- Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Ribosomal protein L27 is a component of the eubacterial large ribosomal subunit that has been shown to play a critical role in substrate stabilization during protein synthesis. This function is mediated by the L27 N-terminus, which protrudes into the peptidyl transferase center. In this report, we demonstrate that L27 in Staphylococcus aureus and other Firmicutes is encoded with an N-terminal extension that is not present in most Gram-negative organisms and is absent from mature ribosomes. We have identified a cysteine protease, conserved among bacteria containing the L27 N-terminal extension, which performs post-translational cleavage of L27. Ribosomal biology in eubacteria has largely been studied in the Gram-negative bacterium Escherichia coli; our findings indicate that there are aspects of the basic biology of the ribosome in S. aureus and other related bacteria that differ substantially from that of the E. coli ribosome. This research lays the foundation for the development of new therapeutic approaches that target this novel pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.