ArticleJournal of cellular and molecular medicine2015
Telocytes damage in endometriosis-affected rat oviduct and potential impact on fertility.
Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
- Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review).International journal of molecular medicine · 2026Review
- From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights.Iranian journal of medical sciences · 2025Review
- Mast Cells, Pancreatic Stellate Cells, and Telocytes in Chronic Pancreatitis: Ultrastructural Study.International journal of molecular sciences · 2025Article
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- Oviductal Oxygen Homeostasis in Patients with Uterine Myoma: Correlation between Hypoxia and Telocytes.International journal of molecular sciences · 2022Article
- Neutrophil depletion reduces interstitial cajal-like cell injury and alleviates inflammation-induced motor dysfunction in guinea-pig gallbladder during acute cholecystitis.Iranian journal of basic medical sciences · 2022Article
- Telocytes and Their Structural Relationships With the Sperm Storage Tube and Surrounding Cell Types in the Utero-Vaginal Junction of the Chicken.Frontiers in veterinary science · 2022Article
- Identification of PDGFRα+ cells in uterine fibroids - link between angiogenesis and uterine telocytes.Archives of medical science : AMS · 2022Article
- Oviductal Telocytes in Patients with Uterine Myoma.Biomedicines · 2021Article
- From TELOCYTES to TELOCYTOPATHIES. Do Recently Described Interstitial Cells Play a Role in Female Idiopathic Infertility?Medicina (Kaunas, Lithuania) · 2020Article
- Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications.Journal of clinical medicine · 2020Review
- Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle.Scientific reports · 2019Article
- Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".Medicina (Kaunas, Lithuania) · 2019Review
- Cyclooxygenase-2 in Endometriosis.International journal of biological sciences · 2019Review
- Telocytes enhanced the proliferation, adhesion and motility of endometrial stromal cells as mediated by the ERK pathway in vitro.American journal of translational research · 2019Article
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis.Journal of translational medicine · 2018Article
- Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis.International journal of genomics · 2018Review
- Immunophenotypic characterization of telocyte-like cells in pterygium.Molecular vision · 2018Article
- Telocytes as potential targets in a cyclophosphamide-induced animal model of premature ovarian failure.Molecular medicine reports · 2016Article
- Telocytes in female reproductive system (human and animal).Journal of cellular and molecular medicine · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women with endometriosis (EMs) have unexplained infertility. The recently identified telocytes (TCs) might participate in the maintenance of structural and functional integrity of oviduct tissue, but so far the involvement of TCs in EMs-affected oviduct tissue and potential impact on fertility capacity remain unknown. By an integrated technique of haematoxylin and eosin staining, in situ immunohistochemistry and double-labelled immunofluorescence staining and electron microscopy approach, TCs were studied in the autotransplantation Sprague-Dawley rat model of EMs-affected oviduct tissue and in sham control, respectively, together with determination of iNOS, COX-2, LPO and estradiol. TCs were found in perivascular connective tissue and smooth muscle bundles in sham oviduct, with typical ultrastructural features (a slender piriform/spindle/triangular cell body, and one or more extremely long prolongations, emerged from cell bodies and extend to various directions), and specific immunophenotype of CD34-positive/vimentin-positive/c-kit-negative. However, in EMs-affected oviduct tissue (grade III), extensive ultrastructural damage (degeneration, discontinue, dissolution and destruction), significant decrease or loss of TCs and interstitial fibrosis were observed, together with elevated level of iNOS, COX-2, LPO and estradiol, thus suggestive of inflammation and ischaemia-induced TCs damage. Based on TCs distribution and intercellular connections, we proposed that such damage might be involved in structural and functional abnormalities of oviduct, such as attenuated intercellular signalling and oviduct contractility, impaired immunoregulation and stem cell-mediated tissue repair, 3-D interstitial architectural derangement and tissue fibrosis. Therefore, TCs damage might provide a new explanation and potential target for EMs-induced tubal damage and fertility disorders.
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