Evidence map›Paper›PMID 25388380›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2015

Quantitative high-efficiency cadmium-zinc-telluride SPECT with dedicated parallel-hole collimation system in obese patients: results of a multi-center study.

Ryo Nakazato, Piotr J Slomka, Mathews Fish, Ronald G Schwartz, Sean W Hayes, Louise E J Thomson, John D Friedman, Mark Lemley, Maria L Mackin, Benjamin Peterson and 4 more

Open access · greenAbstract readEvaluation StudyMulticenter Study
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Detection and quantification of myocardial scar and LVEF with high efficiency digital SPECT: The expanding value proposition for clinical cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  3. Article
  4. Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  5. Article
  6. Deep learning prediction of quantitative coronary angiography values using myocardial perfusion images with a CZT camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  7. Automated quantitative analysis of CZT SPECT stratifies cardiovascular risk in the obese population: Analysis of the REFINE SPECT registry.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  8. Radiation exposure after myocardial perfusion imaging with Cadmium-Zinc-Telluride camera versus conventional camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  9. The magic of improved crystal technology coupled with better resolution: Novel imaging findings may promise improved disease detection.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  10. Article
  11. Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  12. Article
  13. Diagnostic implications of CZT SPECT and impact of CT attenuation correction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  14. Factors affecting appearance of a normal myocardial perfusion scan.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  15. Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Review
  16. Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  17. Article
  18. Quantification with normal limits: New cameras and low-dose imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  19. Comparative analysis of full-time, half-time, and quarter-time myocardial ECG-gated SPECT quantification in normal-weight and overweight patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  20. Quantitation of left ventricular ejection fraction reserve from early gated regadenoson stress Tc-99m high-efficiency SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Ryo NakazatoDepartment of Imaging, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Taper Building Suite 1258, Los Angeles, CA, 90048, USA.
Piotr J Slomka
Mathews Fish
Ronald G Schwartz
Sean W Hayes
Louise E J Thomson
John D Friedman
Mark Lemley
Maria L Mackin
Benjamin Peterson
Arielle M Schwartz
Jesse A Doran
Guido Germano
Daniel S Berman
Cedars-Sinai Medical Center · USUniversity of Rochester Medical Center · USSacred Heart Medical Center · US

Funding

Quantitative Prediction of Disease and Outcomes from Next Generation SPECT and CTR01HL089765 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SLOMKA, PIOTR J · 2007 to 2021
$6.1M
NHLBI NIH HHS R01 HL089765NHLBI NIH HHS R01-HL089765
6 · The paper itself

Abstract

backgroundObesity is a common source of artifact on conventional SPECT myocardial perfusion imaging (MPI). We evaluated image quality and diagnostic performance of high-efficiency (HE) cadmium-zinc-telluride parallel-hole SPECT MPI for coronary artery disease (CAD) in obese patients. METHODS AND

results118 consecutive obese patients at three centers (BMI 43.6 ± 8.9 kg·m(-2), range 35-79.7 kg·m(-2)) had upright/supine HE-SPECT and invasive coronary angiography > 6 months (n = 67) or low likelihood of CAD (n = 51). Stress quantitative total perfusion deficit (TPD) for upright (U-TPD), supine (S-TPD), and combined acquisitions (C-TPD) was assessed. Image quality (IQ; 5 = excellent; < 3 nondiagnostic) was compared among BMI 35-39.9 (n = 58), 40-44.9 (n = 24) and ≥45 (n = 36) groups. ROC curve area for CAD detection (≥50% stenosis) for U-TPD, S-TPD, and C-TPD were 0.80, 0.80, and 0.87, respectively. Sensitivity/specificity was 82%/57% for U-TPD, 74%/71% for S-TPD, and 80%/82% for C-TPD. C-TPD had highest specificity (P = .02). C-TPD normalcy rate was higher than U-TPD (88% vs 75%, P = .02). Mean IQ was similar among BMI 35-39.9, 40-44.9 and ≥45 groups [4.6 vs 4.4 vs 4.5, respectively (P = .6)]. No patient had a nondiagnostic stress scan.

conclusionsIn obese patients, HE-SPECT MPI with dedicated parallel-hole collimation demonstrated high image quality, normalcy rate, and diagnostic accuracy for CAD by quantitative analysis of combined upright/supine acquisitions.

Indexed as

ArtifactsCadmium CompoundsCaliforniaCoronary Artery DiseaseEquipment DesignEquipment Failure AnalysisFemaleHumansImage EnhancementMaleMiddle AgedMyocardial Perfusion ImagingObesityReproducibility of ResultsSelenium CompoundsSensitivity and SpecificityCadmium Compoundscadmium selenideSelenium CompoundsZinc Compoundszinc selenide

Identifiers

PMID25388380
PMCPMC4355061
OpenAlexW2083708620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.