Evidence map›Paper›PMID 25387901›Full record

SynthesisEuropean journal of clinical nutrition2015

Dietary fiber effects in chronic kidney disease: a systematic review and meta-analysis of controlled feeding trials.

L Chiavaroli, A Mirrahimi, J L Sievenpiper, D J A Jenkins, P B Darling

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01844882 (The Effects of Dietary Fiber on Uremic Retention Solutes in CKD), which is not on this map. Cited by 70 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 4 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01844882 completednot on this map

The Effects of Dietary Fiber on Uremic Retention Solutes in CKD: A Systematic Review and Meta-analysis

TypeobservationalSponsorUnity Health TorontoRan2012 to 2013Enrolled1ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 173 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Plant-Based Diets across the Spectrum of Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  13. Review
  14. Review
  15. Dietary Fiber Intake and Clinical Outcomes in Chronic Kidney Disease: A Report From the Chronic Renal Insufficiency Cohort Study.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2025
    Article
  16. The Gut-Kidney Axis in Chronic Kidney Diseases.Diagnostics (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

L Chiavaroli1] Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada [2] Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
A Mirrahimi1] Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada [2] School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.
J L Sievenpiper1] Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada [2] Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada [3] Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada [4] Division of Endocrinology, Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
D J A Jenkins1] Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada [2] Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada [3] Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada [4] Division of Endocrinology, Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
P B Darling1] Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada [2] Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada [3] Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
University of Toronto · CASt. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesChronic kidney disease (CKD) is a major health concern associated with increased risk of cardiovascular disease, morbidity and mortality. Current CKD practice guidelines overlook dietary fiber, which is chronically low in the renal diet. However, increasing dietary fiber has been proposed to ameliorate the progress of CKD. We therefore conducted a systematic review and meta-analysis on the effect of dietary fiber intake on serum urea and creatinine as classical markers of renal health in individuals with CKD. SUBJECTS/

methodsWe searched MEDLINE, EMBASE, CINHAL and the Cochrane Library for relevant clinical trials with a follow-up ⩾7 days. Data were pooled by the generic inverse variance method using random-effects models and expressed as mean difference (MD) with 95% confidence intervals (95% CIs). Heterogeneity was assessed by the Cochran Q statistic and quantified by I(2).

resultsA total of 14 trials involving 143 participants met the eligibility criteria. Dietary fiber supplementation significantly reduced serum urea and creatinine levels in the primary pooled analyses (MD, -1.76 mmol/l (95% CI, -3.00, -0.51), P<0.01 and MD, -22.83 mmol/l (95% CI, -42.63, -3.02), P=0.02, respectively) with significant evidence of interstudy heterogeneity only in the analysis of serum urea.

conclusionsThis is the first study to summarize the potential beneficial effects of dietary fiber in the CKD population demonstrating a reduction in serum urea and creatinine, as well as highlighting the lack of clinical trials on harder end points. Larger, longer, higher-quality clinical trials measuring a greater variety of uremic toxins in CKD are required (NCT01844882).

Indexed as

Dietary SupplementsBiomarkersCombined Modality TherapyControlled Clinical Trials as TopicCreatinineCross-Over StudiesDietary FiberDisease ProgressionFermentationGastrointestinal MicrobiomeHumansPractice Guidelines as TopicRenal DialysisRenal Insufficiency, ChronicUreaBiomarkersCreatinineDietary FiberUrea

Identifiers

PMID25387901
OpenAlexW2061510481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.