ArticlePsychophysiology2014
In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes.
Article in Psychophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.Biological psychiatry · 2019Pooled it
- Mapping 60 Years of Psychophysiology: A Bibliometric Analysis of Journal Performance, Authorship Trends, and Thematic Evolution.Psychophysiology · 2025Review
- Validating Online Measures of Cognitive Ability in Genes for Good, a Genetic Study of Health and Behavior.Assessment · 2020Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
- Miscellanea Dependent generalized functional linear models.Biometrika · 2017Article
- A functional U-statistic method for association analysis of sequencing data.Genetic epidemiology · 2017Article
- Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.Psychological medicine · 2017Article
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Next-generation genotype imputation service and methods.Nature genetics · 2016Article
- A computational method for genotype calling in family-based sequencing data.BMC bioinformatics · 2016Article
- Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology.Psychophysiology · 2015Article
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- Rare variant association studies: considerations, challenges and opportunities.Genome medicine · 2015Article
- Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.Psychophysiology · 2014Article
- Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview.Psychophysiology · 2014Review
- Genetic associations of nonsynonymous exonic variants with psychophysiological endophenotypes.Psychophysiology · 2014Article
- Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study.Psychophysiology · 2014Article
- The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward.Psychological inquiryArticle
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Whole genome sequencing was completed on 1,325 individuals from 602 families, identifying 27 million autosomal variants. Genetic association tests were conducted for those individuals who had been assessed for one or more of 17 endophenotypes (N range = 802-1,185). No significant associations were found. These 27 million variants were then imputed into the full sample of individuals with psychophysiological data (N range = 3,088-4,469) and again tested for associations with the 17 endophenotypes. No association was significant. Using a gene-based variable threshold burden test of nonsynonymous variants, we obtained five significant associations. These findings are preliminary and call for additional analysis of this rich sample. We argue that larger samples, alternative study designs, and additional bioinformatics approaches will be necessary to discover associations between these endophenotypes and genomic variation.
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