ArticlePsychophysiology2014
Genetic associations of nonsynonymous exonic variants with psychophysiological endophenotypes.
Article in Psychophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.Biological psychiatry · 2019Pooled it
- A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.Molecular psychiatry · 2021Article
- Individual differences in the processing of smoking-cessation video messages: An imaging genetics study.Biological psychology · 2017Article
- Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.Psychological medicine · 2017Article
- Lipoquality control by phospholipase AProceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Review
- Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma.Oncology letters · 2016Article
- Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology.Psychophysiology · 2015Article
- Assessing the Power of Exome Chips.PloS one · 2015Article
- Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study.Psychophysiology · 2014Article
- Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview.Psychophysiology · 2014Review
- In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes.Psychophysiology · 2014Article
- Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study.Psychophysiology · 2014Article
- Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.Psychophysiology · 2014Article
- The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward.Psychological inquiryArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We mapped ∼85,000 rare nonsynonymous exonic single nucleotide polymorphisms (SNPs) to 17 psychophysiological endophenotypes in 4,905 individuals, including antisaccade eye movements, resting EEG, P300 amplitude, electrodermal activity, affect-modulated startle eye blink. Nonsynonymous SNPs are predicted to directly change or disrupt proteins encoded by genes and are expected to have significant biological consequences. Most such variants are rare, and new technologies can efficiently assay them on a large scale. We assayed 247,870 mostly rare SNPs on an Illumina exome array. Approximately 85,000 of the SNPs were polymorphic, rare (MAF < .05), and nonsynonymous. Single variant association tests identified a SNP in the PARD3 gene associated with theta resting EEG power. The sequence kernel association test, a gene-based test, identified a gene PNPLA7 associated with pleasant difference startle, the difference in startle magnitude between pleasant and neutral images. No other single nonsynonymous variant, or gene-based group of variants, was strongly associated with any endophenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.