ArticlePsychophysiology2014
Heritability and molecular genetic basis of acoustic startle eye blink and affectively modulated startle response: a genome-wide association study.
Article in Psychophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Genetic and Environmental Influences on Fear Learning and Generalization.Psychophysiology · 2025Article
- Family study of the startle reflex and event-related potentials in anticipation of predictable and unpredictable threat in adolescents and their parents.Psychophysiology · 2023Article
- Posttraumatic stress symptom dimensions and brain responses to startling auditory stimuli in combat veterans.Journal of abnormal psychology · 2021Article
- Fear-potentiated startle response as an endophenotype: Evaluating metrics and methods for genetic applications.Psychophysiology · 2019Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
- GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.Molecular psychiatry · 2017Article
- Heritability of startle reactivity and affect modified startle.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.Psychological medicine · 2017Article
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Review
- Comparing the validity of informant and self-reports of personality using laboratory indices of emotional responding as criterion variables.Psychophysiology · 2016Article
- Psychometric properties of startle and corrugator response in NPU, affective picture viewing, and resting state tasks.Psychophysiology · 2016Article
- Psychophysiology of threat response, paradigm shifts in psychiatry, and RDoC: Implications for genetic investigation of psychopathology.Psychophysiology · 2016Article
- Animal Models of Maladaptive Traits: Disorders in Sensorimotor Gating and Attentional Quantifiable Responses as Possible Endophenotypes.Frontiers in psychology · 2016Review
- Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology.Psychophysiology · 2015Article
- Empirically based comparisons of the reliability and validity of common quantification approaches for eyeblink startle potentiation in humans.Psychophysiology · 2015Article
- Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study.Psychophysiology · 2014Article
- In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes.Psychophysiology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Acoustic startle responses have been studied extensively in relation to individual differences and psychopathology. We examined three indices of the blink response in a picture-viewing paradigm-overall startle magnitude across all picture types, and aversive and pleasant modulation scores-in 3,323 twins and parents. Biometric models and molecular genetic analyses showed that half the variance in overall startle was due to additive genetic effects. No single nucleotide polymorphism was genome-wide significant, but GRIK3 produced a significant effect when examined as part of a candidate gene set. In contrast, emotion modulation scores showed little evidence of heritability in either biometric or molecular genetic analyses. However, in a genome-wide scan, PARP14 produced a significant effect for aversive modulation. We conclude that, although overall startle retains potential as an endophenotype, emotion-modulated startle does not.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.