ArticlePsychophysiology2014
Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study.
Article in Psychophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Neurophysiology in psychosis: The quest for disease biomarkers.Translational psychiatry · 2022Review
- Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?Frontiers in psychology · 2022Review
- A genome-wide association study of the longitudinal course of executive functions.Translational psychiatry · 2021Article
- Precision Psychiatry: Biomarker-Guided Tailored Therapy for Effective Treatment and Prevention in Major Depression.Advances in experimental medicine and biology · 2021Review
- What External Variables Affect Sensorimotor Rhythm Brain-Computer Interface (SMR-BCI) Performance?HCA healthcare journal of medicine · 2021Review
- Association Between P300 Responses to Auditory Oddball Stimuli and Clinical Outcomes in the Psychosis Risk Syndrome.JAMA psychiatry · 2019Article
- Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300.Schizophrenia bulletin · 2019Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
- Article
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.Psychological medicine · 2017Article
- Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Review
- One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study.Psychophysiology · 2016Article
- Achieving success with the Research Domain Criteria (RDoC): Going beyond the matrix.Psychophysiology · 2016Article
- Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology.Psychophysiology · 2015Article
- Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth.Current addiction reports · 2015Article
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- Heritability and molecular genetic basis of antisaccade eye tracking error rate: a genome-wide association study.Psychophysiology · 2014Article
- Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview.Psychophysiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
P3 amplitude is a candidate endophenotype for disinhibitory psychopathology, psychosis, and other disorders. The present study is a comprehensive analysis of the behavioral- and molecular-genetic basis of P3 amplitude and a P3 genetic factor score in a large community sample (N = 4,211) of adolescent twins and their parents, genotyped for 527,829 single nucleotide polymorphisms (SNPs). Biometric models indicated that as much as 65% of the variance in each measure was due to additive genes. All SNPs in aggregate accounted for approximately 40% to 50% of the heritable variance. However, analyses of individual SNPs did not yield any significant associations. Analyses of individual genes did not confirm previous associations between P3 amplitude and candidate genes but did yield a novel association with myelin expression factor 2 (MYEF2). Main effects of individual variants may be too small to be detected by GWAS without larger samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.