Evidence map›Paper›PMID 25387453›Full record

ArticleJournal of cell communication and signaling2014

Dose response biology of resveratrol in obesity.

Giovanni Scapagnini, Sergio Davinelli, Taku Kaneko, Guido Koverech, Angela Koverech, Edward J Calabrese, Vittorio Calabrese

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell communication and signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. The Role of Resveratrol Administration in Human Obesity.International journal of molecular sciences · 2021
    Review
  7. Pleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown.Oxidative medicine and cellular longevity · 2021
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. MetabolaidNutrients · 2018
    Article
  13. Article
  14. Article
  15. Ageing: from inflammation to cancer.Immunity & ageing : I & A · 2018
    Review
  16. Article
  17. Polyphenols: a Promising Nutritional Approach to Prevent or Reduce the Progression of Prehypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016
    Review
  18. It's all in your gut and mind.Journal of cell communication and signaling · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Giovanni ScapagniniDepartment of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
Sergio Davinelli
Taku Kaneko
Guido Koverech
Angela Koverech
Edward J Calabrese
Vittorio Calabrese
University of Catania · ITUniversity of Molise · ITOregon Health & Science University · USUniversity of Massachusetts Amherst · USUniversity of Sannio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a major health problem throughout the world, and it is increasing both in prevalence and severity. Pharmaceutical approaches developed for the treatment of obesity, despite short-term benefits, often are associated with rebound weight gain after the cessation of drug use and serious side effects deriving from the medication can occur. Resveratrol has been well recognized as an anti-obesity substance for its lipid-lowering function as well as calorie-restriction effect. This polyphenol induces hormetic dose responses in a wide range of biological models, affecting numerous endpoints of biomedical and therapeutic significance. From an hormetic standpoint, we will discuss the potential relevance of resveratrol in the management of obesity and related comorbid conditions, emphasizing its ability to control simultaneously various pathological mechanisms associated with obesity.

Identifiers

PMID25387453
PMCPMC4390800
OpenAlexW2056059444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.