ReviewMolecular biology reports2015
Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview.
Review in Molecular biology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Association between the FTOrs8050136 polymorphism and cancer risk: a meta-analysis.Familial cancer · 2016Pooled it
- Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort.Cancers · 2025Article
- Elucidating shared genetic association between female body mass index and preeclampsia.Communications biology · 2025Article
- Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.Journal of the National Cancer Center · 2025Review
- Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family.Current issues in molecular biology · 2024Review
- The antagonistic effect of FTO on METTL14 promotes AKT3 mJournal of cancer research and clinical oncology · 2024Article
- FTO in health and disease.Frontiers in cell and developmental biology · 2024Review
- Current insights on m6A RNA modification in acute leukemia: therapeutic targets and future prospects.Frontiers in oncology · 2024Review
- Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Review
- Revealing the Catalytic Strategy of FTO.Chem catalysis · 2023Article
- NAdvances in experimental medicine and biology · 2023Article
- Article
- The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake.Journal of cellular and molecular medicine · 2022Article
- Multidisciplinary Progress in Obesity Research.Genes · 2022Review
- FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.Clinical & experimental metastasis · 2022Article
- FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an mMolecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- RNAME: A comprehensive database of RNA modification enzymes.Computational and structural biotechnology journal · 2022Article
- Association of Leptin Receptor Q223R Gene Polymorphism and Breast Cancer Patients: A Case Control Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer.Pharmacogenomics and personalized medicine · 2022Article
- The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells.RNA biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FTO (fat mass and obesity-associated) gene has a strong linkage disequilibrium block, within which SNPs have been identified that are involved in the development of obesity. Recently some of these variants have also been associated with cancer. However, identification of the possible mechanisms that could explain these associations has proven to be elusive. It has been found that FTO polymorphisms can regulate the expression of genes at large kilobases of distance as well as the expression of the FTO gene itself, and regions for transcription factor binding. To date it has been observed that variants rs9939609, rs17817449, rs8050136, rs1477196, rs6499640, rs16953002, rs11075995 and rs1121980 are associated with the risk of developing cancer. Some studies have produced negative results when comparing the same polymorphisms, but make a simple association between polymorphic variants and cancer, have proved difficult because this relation is by nature multifactorial. A certain degree of variation resulting from the improper design of studies or processing of data can lead to erroneous conclusions. However, it is now unquestionable that certain FTO polymorphisms regulate genetic expression related to cancer susceptibility, although this field is just beginning to be understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.