ArticlePloS one2014
Cytomegalovirus infection in inflammatory bowel disease is not associated with worsening of intestinal inflammatory activity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Cytomegalovirus in inflammatory bowel disease: A systematic review.World journal of gastroenterology · 2016Pooled it
- Cytomegalovirus Detection by PCR on Fresh and Formalin-Fixed Colon Tissue Biopsies of Children with Colitis: A Prospective Cohort Study.Iranian journal of medical sciences · 2025Article
- Diverticular perforation with exclusive local invasion in cytomegalovirus infection during ganciclovir treatment: an autopsy case report.Annals of medicine and surgery (2012) · 2025Article
- Review
- Prevalence of opportunistic infections in Syrian inflammatory bowel disease patients on biologic therapy: a multi-center retrospective cross-sectional study.BMC infectious diseases · 2025Article
- The role of total polysaccharides fromFrontiers in pharmacology · 2025Article
- Long-Term Follow Up of Patients Treated for Inflammatory Bowel Disease and Cytomegalovirus Colitis.Diagnostics (Basel, Switzerland) · 2024Article
- Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment.Journal of clinical medicine · 2023Review
- Article
- Article
- Clinical Implications of the CMV-Specific T-Cell Response and Local or Systemic CMV Viral Replication in Patients With Moderate to Severe Ulcerative Colitis.Open forum infectious diseases · 2019Article
- Diagnosis and Management of CMV Colitis.Current infectious disease reports · 2019Review
- Cytomegalovirus infection in ulcerative colitis assessed by quantitative polymerase chain reaction: risk factors and effects of immunosuppressants.Journal of clinical biochemistry and nutrition · 2018Article
- Prevalence of cytomegalovirus infection in patients with ulcerative colitis: a prospective cross-sectional study in Tehran, Iran.Iranian journal of microbiology · 2018Article
- CMV Infection in Pediatric IBD.Current gastroenterology reports · 2018Review
- Approach to cytomegalovirus infections in patients with ulcerative colitis.The Korean journal of internal medicine · 2017Review
- Cytomegalovirus, inflammatory bowel disease, and anti-TNFα.International journal of colorectal disease · 2017Observational
- Association of Human Cytomegalovirus with Hodgkin’s Disease and Non-Hodgkin’s lymphomasAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Assessment of Disease Severity and Role of Cytomegalo Virus Infection in Patients with Ulcerative Colitis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study.BMC gastroenterology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytomegalovirus is highly prevalent virus and usually occurs in immunocompromised patients. The pathophysiology and treatment of inflammatory bowel disease often induce a state of immunosuppression. Because this, there are still doubts and controversies about the relationship between inflammatory bowel disease and cytomegalovirus.
aimEvaluate the frequency of cytomegalovirus in patients with inflammatory bowel disease and identify correlations.
methodsPatients with inflammatory bowel disease underwent an interview, review of records and collection of blood and fecal samples. The search for cytomegalovirus was performed by IgG and IgM blood serology, by real-time PCR in the blood and by qualitative PCR in feces. Results were correlated with red blood cell levels, C-reactive protein levels, erythrocyte sedimentation rates and fecal calprotectin levels for each patient.
resultsAmong the 400 eligible patients, 249 had Crohn's disease, and 151 had ulcerative colitis. In the group of Crohn's disease, 67 of the patients had moderate or severe disease, but 126 patients presented with active disease, based on the evaluation of the fecal calprotectin. In patients with ulcerative colitis, only 21 patients had moderate disease, but 76 patients presented with active disease, based on the evaluation of the fecal calprotectin. A large majority of patients had positive CMV IgG. Overall, 10 patients had positive CMV IgM, and 9 patients had a positive qualitative detection of CMV DNA by PCR in the feces. All 400 patients returned negative results after the quantitative detection of CMV DNA in blood by real-time PCR. Analyzing the 19 patients with active infections, we only found that such an association occurred with the use of combined therapy (anti-TNF-alpha + azathioprine).
conclusionThe findings show that latent cytomegalovirus infections are frequent and active cytomegalovirus infection is rare. We did not find any association between an active infection of CMV and inflammatory bowel disease activity.
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