ReviewAnnual review of animal biosciences2015
The impact of the milk glycobiome on the neonate gut microbiota.
Review in Annual review of animal biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Role of HIV exposure and infection in relation to neonatal GBS disease and rectovaginal GBS carriage: a systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Probiotics Prevent Late-Onset Sepsis in Human Milk-Fed, Very Low Birth Weight Preterm Infants: Systematic Review and Meta-Analysis.Nutrients · 2017Pooled it
- Breastfeeding and COVID-19: From Nutrition to Immunity.Frontiers in immunologyPooled it
- Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions.Journal of translational medicine · 2026Review
- Quantitative Profiling of Human Milk Oligosaccharides Across Asian Countries Reveals Secretor-Dependent Variations and Implications for Infant Nutrition.International journal of molecular sciences · 2026Article
- Time-resolved growth of diverse human-associatedMicrobiology spectrum · 2026Article
- Gut Microbiota Dysbiosis Remodels the Lysine Acetylome of the Mouse Cecum in Early Life.Biology · 2025Article
- Article
- Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants.Microbiome · 2025Article
- The influence of human milk composition and its microbiome on the gut microecology and early growth and development of preterm infants (the YI study): protocol design and cohort profile.Frontiers in nutrition · 2025Article
- Evaluating continuous nanosecond pulsed electric field (nsPEF) treatment as a non-thermal alternative for human milk pasteurisation.PloS one · 2025Article
- Effects of multistrain Bifidobacteria and Lactobacillus probiotics on HMO compositions after supplementation to pregnant women at threatening preterm delivery: design of the randomized clinical PROMO trial.Molecular and cellular pediatrics · 2024Review
- Alterations of milk oligosaccharides in mothers with gestational diabetes mellitus impede colonization of beneficial bacteria and development of RORγtGut microbes · 2023Article
- Chemical Synthesis of Human Milk Oligosaccharides: para-Lacto-N-hexaose and para-Lacto-N-neohexaose.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- The Influence of Oligosaccharides when Measuring Lactose and Total Carbohydrates in Human Milk and Comparison of Methods.The Journal of nutrition · 2023Article
- Creation of a milk oligosaccharide database, MilkOligoDB, reveals common structural motifs and extensive diversity across mammals.Scientific reports · 2023Article
- Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health.Biomedicines · 2023Review
- Early-life dietary exposures mediate persistent shifts in the gut microbiome and visceral fat metabolism.American journal of physiology. Cell physiology · 2023Article
- Effect of milk fat globules on growth and metabolism in rats fed an unbalanced diet.Frontiers in nutrition · 2023Article
- Two-sample Mendelian randomization analysis investigates causal associations between gut microbiota and attention deficit hyperactivity disorder.Frontiers in microbiology · 2023Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Human milk is a complete source of nourishment for the infant. Exclusive breastfeeding not only sustains the infant's development but also guides the proliferation of a protective intestinal microbiota. Among the many components of milk that modulate the infant gut microbiota, the milk glycans, which comprise free oligosaccharides, glycoproteins, and glycolipids, are increasingly recognized as drivers of microbiota development and overall gut health. These glycans may display pleiotropic functions, conferring protection against infectious diseases and also acting as prebiotics, selecting for the growth of beneficial intestinal bacteria. The prebiotic effect of milk glycans has direct application to prevention of diseases such as necrotizing enterocolitis, a common and devastating disease of preterm infants. In this article, we review the impact of the human (and bovine) milk glycome on gut health through establishment of a milk-oriented microbiota in the neonate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.