Evidence map›Paper›PMID 25387223›Full record

ReviewPostgraduate medicine2014

Testosterone supplementation therapy in the treatment of patients with metabolic syndrome.

Jason R Kovac, Jason Kovac, Alexander W Pastuszak, Dolores J Lamb, Larry I Lipshultz

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Postgraduate medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Vascular Pathways of Testosterone: Clinical Implications.Journal of cardiovascular translational research · 2020
    Review
  4. Article
  5. Article
  6. Review
  7. A critical analysis of the 2014 CUA guidelines for erectile dysfunction: Is there more that can be done?Canadian Urological Association journal = Journal de l'Association des urologues du Canada
    Article
4 · The record

Corrections and comments

  • Erratum issued
    Erratum.2015 · Kovac, Jason [corrected to Kovac, Jason R]
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jason R Kovac
Jason KovacScott Department of Urology and The Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX. Kovac@bcm.edu.
Alexander W Pastuszak
Dolores J Lamb
Larry I Lipshultz
Baylor College of Medicine · US

Funding

ZONA PELLUCIDA BINDING PROTEINS IN SPERM-EGG INTERACTIONSP01HD036289 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2000 to 2010
$7.5M
Improving the Diagnosis of Congenital Genitourinary Defects.R01DK078121 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAMB, DOLORES JEAN · 2007 to 2021
$4.8M
K-12: Male Reproductive Health Research (MRHR) Career Development Program at BCMK12HD073917 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LAMB, DOLORES JEAN · 2012 to 2016
$1.7M
NICHD NIH HHS K12 HD073917NICHD NIH HHS K12 HD073917-01NICHD NIH HHS P01 HD036289NICHD NIH HHS P01HD36289NIDDK NIH HHS 1R01DK078121NIDDK NIH HHS R01 DK078121
6 · The paper itself

Abstract

Metabolic syndrome (MetS) comprises a clinical complex of patient risk factors, including increased waist circumference, high triglyceride levels, low high-density lipoprotein cholesterol level, high blood pressure, and insulin resistance, the presence of which increases the likelihood of developing diabetes and cardiovascular disease. With a quarter of the American adult population affected, MetS and type 2 diabetes mellitus have been referred to as the most significant public health threats of the 21st century. Lifestyle modification and weight loss are recommended, however, no specific pharmacologic treatment is known. Given that low levels of testosterone have been implicated in the pathogenesis of MetS and an inverse relationship exists between circulating testosterone levels and the development of MetS, it is tempting to speculate that men with MetS may benefit from testosterone supplementation therapy. As such, our review examines the role of testosterone and the use of testosterone supplementation therapy as a treatment in men with MetS.

Indexed as

AndrogensHumansLife StyleMetabolic SyndromeObesitySex Hormone-Binding GlobulinTestosteroneAndrogensSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID25387223
PMCPMC4942302
OpenAlexW2008711822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.