ArticleJournal of biomedical optics2014
Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near-infrared wavelengths.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis: a first-in-human clinical trial.Journal of biomedical optics · 2021Trial
- Optical phantoms for the characterization and validation of imaging and spectroscopy: a review.Biophotonics discovery · 2026Review
- Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging.Journal of biomedical optics · 2025Article
- All-opticalPhotoacoustics · 2025Article
- Human Skin Models in Biophotonics: Materials, Methods, and Applications.Advanced healthcare materials · 2025Review
- Development of a multiparameter phantom system for multispectral imaging.Biomedical optics express · 2025Article
- Direct 3-D printing of complex optical phantoms using dynamic filament mixing.Scientific reports · 2025Article
- Speckle-illumination spatial frequency domain imaging with a stereo laparoscope for profile-corrected optical property mapping.Journal of biomedical optics · 2025Article
- Fabrication of complex optical phantoms using on-the-fly multi-filament mixing 3-D printing.Research square · 2024Article
- Application of machine learning algorithms for accurate determination of bilirubin level on in vitro engineered tissue phantom images.Scientific reports · 2024Article
- Analysis of Acousto-Optic Phenomenon in SAW Acoustofluidic Chip and Its Application in Light Refocusing.Micromachines · 2023Article
- Development of a platform for broadband, spectra-fitted, tissue optical phantoms.Journal of biomedical optics · 2023Article
- Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation.Nature biomedical engineering · 2022Review
- Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties.Journal of biomedical optics · 2021Article
- Quantitative Photothermal Characterization with Bioprinted 3D Complex Tissue Constructs for Early-Stage Breast Cancer Therapy Using Gold Nanorods.Advanced healthcare materials · 2021Article
- Direct laser writing of a titanium dioxide-laden retinal cone phantom for adaptive optics-optical coherence tomography.Optical materials express · 2020Article
- Experimental validation of a spectroscopic Monte Carlo light transport simulation technique and Raman scattering depth sensing analysis in biological tissue.Journal of biomedical optics · 2020Article
- Spatial frequency domain imaging in 2019: principles, applications, and perspectives.Journal of biomedical optics · 2019Review
- Real-time, wide-field, and quantitative oxygenation imaging using spatiotemporal modulation of light.Journal of biomedical optics · 2019Article
- Fabrication of 3D Fingerprint Phantoms via Unconventional Polycarbonate Molding.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Optical phantoms are used in the development of various imaging systems. For certain applications, the development of thin phantoms that simulate the physical size and optical properties of tissue is important. Here, we demonstrate a method for producing thin phantom layers with tunable optical properties using poly(dimethylsiloxane) (PDMS) as a substrate material. The thickness of each layer (between 115 and 880 μm) was controlled using a spin coater. The reduced scattering and absorption coefficients were controlled using titanium dioxide and alcohol-soluble nigrosin, respectively. These optical coefficients were quantified at six discrete wavelengths (591, 631, 659, 691, 731, and 851 nm) at varying concentrations of titanium dioxide and nigrosin using spatial frequency domain imaging. From the presented data, we provide lookup tables to determine the appropriate concentrations of scattering and absorbing agents to be used in the design of PDMS-based phantoms with specific optical coefficients. In addition, heterogeneous phantoms mimicking the layered features of certain tissue types may be fabricated from multiple stacked layers, each with custom optical properties. These thin, tunable PDMS optical phantoms can simulate many tissue types and have broad imaging calibration applications in endoscopy, diffuse optical spectroscopic imaging, and optical coherence tomography, etc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.