ArticlePloS one2014
Streptococcus mitis induces conversion of Helicobacter pylori to coccoid cells during co-culture in vitro.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Review
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- Invasive guests: the role of non-oral bacteria in oral dysbiosis and systemic health.Journal of oral microbiology · 2026Review
- CoccoidVirulence · 2025Review
- Microbial oncogenesis within the gastric niche: how the gastric microbiota influencesFrontiers in microbiology · 2025Review
- Polymicrobial interactions ofJournal of oral microbiology · 2025Review
- The Influence of Gastric Microbiota and Probiotics inBiomedicines · 2024Review
- Comparison of three methods for generating the coccoid form of Helicobacter pylori and proteomic analysis.BMC microbiology · 2024Article
- Unveiling the gastric microbiota: implications for gastric carcinogenesis, immune responses, and clinical prospects.Journal of experimental & clinical cancer research : CR · 2024Review
- Review
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- Interrelation: gastric microbiota - acid-dependent diseases, and more….Medicine and pharmacy reports · 2021Article
- Effect of gastric microbiota on quadrupleWorld journal of gastroenterology · 2021Article
- Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?BMC microbiology · 2021Review
- Potential Role of Biofilm Formation in the Development of Digestive Tract Cancer With Special Reference toFrontiers in microbiology · 2019Article
- Article
- Engineering microbes for targeted strikes against human pathogens.Cellular and molecular life sciences : CMLS · 2018Review
- Detection of gastritis-associated pathogens by culturing of gastric juice and mucosa.International journal of clinical and experimental pathology · 2018Article
- A proposed role for diffusible signal factors in the biofilm formation and morphological transformation of Helicobacter pylori.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Review
- Morphology ofPrzeglad gastroenterologiczny · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) is a major gastric pathogen that has been associated with humans for more than 60,000 years. H. pylori causes different gastric diseases including dyspepsia, ulcers and gastric cancers. Disease development depends on several factors including the infecting H. pylori strain, environmental and host factors. Another factor that might influence H. pylori colonization and diseases is the gastric microbiota that was overlooked for long because of the belief that human stomach was a hostile environment that cannot support microbial life. Once established, H. pylori mainly resides in the gastric mucosa and interacts with the resident bacteria. How these interactions impact on H. pylori-caused diseases has been poorly studied in human. In this study, we analyzed the interactions between H. pylori and two bacteria, Streptococcus mitis and Lactobacillus fermentum that are present in the stomach of both healthy and gastric disease human patients. We have found that S. mitis produced and released one or more diffusible factors that induce growth inhibition and coccoid conversion of H. pylori cells. In contrast, both H. pylori and L. fermentum secreted factors that promote survival of S. mitis during the stationary phase of growth. Using a metabolomics approach, we identified compounds that might be responsible for the conversion of H. pylori from spiral to coccoid cells. This study provide evidences that gastric bacteria influences H. pylori physiology and therefore possibly the diseases this bacterium causes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.