ArticleStem cells and development2015
Label-retaining stromal cells in mouse endometrium awaken for expansion and repair after parturition.
Article in Stem cells and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice.Biological research · 2024Article
- Repopulation of autophagy-deficient stromal cells with autophagy-intact cells after repeated breeding in uterine mesenchyme-specific Atg7 knockout mice.Clinical and experimental reproductive medicine · 2023Article
- Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine.International journal of molecular sciences · 2022Review
- The role of Notch signaling in endometrial mesenchymal stromal/stem-like cells maintenance.Communications biology · 2022Article
- Review
- Hypoxia Regulates the Self-Renewal of Endometrial Mesenchymal Stromal/Stem-like Cells via Notch Signaling.International journal of molecular sciences · 2022Article
- WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells.Frontiers in cell and developmental biology · 2022Article
- Bone marrow-derived progenitor cells contribute to remodeling of the postpartum uterus.Stem cells (Dayton, Ohio) · 2021Article
- Stem Cells and the Endometrium: From the Discovery of Adult Stem Cells to Pre-Clinical Models.Cells · 2021Review
- The Elusive Endometrial Epithelial Stem/Progenitor Cells.Frontiers in cell and developmental biology · 2021Review
- Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation.Stem cell research & therapy · 2020Article
- Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung.Stem cells international · 2019Article
- Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology.Bioengineering (Basel, Switzerland) · 2018Review
- Mapping of estradiol binding sites through receptor micro-autoradiography in the endometrial stroma of early pregnant mice.Histochemistry and cell biology · 2017Article
- Endometritis andStem cells international · 2017Article
- Endometrial Stem Cells and Their Applications in Intrauterine Adhesion.Cell transplantationReview
- Endometrial stem/progenitor cells: the first 10 years.Human reproduction updateReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human and mouse endometrium undergo dramatic cellular reorganization during pregnancy and postpartum. Somatic stem cells maintain homeostasis of the tissue by providing a cell reservoir for regeneration. We hypothesized that endometrial cells with quiescent properties (stem/progenitor cells) were involved in the regeneration of the endometrial tissue. Given that stem cells divide infrequently, they can retain the DNA synthesis label [bromodeoxyuridine (BrdU)] after a prolonged chase period. In this study, prepubertal mice were pulsed with BrdU and after a 6-week chase a small population of label-retaining stromal cells (LRSC) was located primarily beneath the luminal epithelium, adjacent to blood vessels, and near the endometrial-myometrial junction. Marker analyses suggested that they were of mesenchymal origin expressing CD44(+), CD90(+), CD140b(+), CD146(+), and Sca-1(+). During pregnancy, nonproliferating LRSC predominately resided at the interimplantation/placental loci of the gestational endometrium. Immediately after parturition, a significant portion of the LRSC underwent proliferation (BrdU(+)/Ki-67(+)) and expressed total and active β-catenin. The β-catenin expression in the LRSC was transiently elevated at postpartum day (PPD) 1. The proliferation of LRSC resulted in a significant decline in the proportion of LRSC in the postpartum uterus. The LRSC returned to dormancy at PPD7, and the percentage of LRSC remained stable thereafter until 11 weeks. This study demonstrated that LRSC can respond efficiently to physiological stimuli upon initiation of uterine involution and return to its quiescent state after postpartum repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.