ArticlePloS one2014
Effects of the use of assisted reproductive technologies and an obesogenic environment on resistance artery function and diabetes biomarkers in mice offspring.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- The effects of assisted reproduction technologies on metabolic health and disease†.Biology of reproduction · 2021Review
- The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.Human reproduction (Oxford, England) · 2020Article
- Absence of Endothelial ERα Results in Arterial Remodeling and Decreased Stiffness in Western Diet-Fed Male Mice.Endocrinology · 2017Article
- Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
- Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice.Endocrinology · 2016Article
- Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.Circulation research · 2016Article
- Maternal Hyperleptinemia Is Associated with Male Offspring's Altered Vascular Function and Structure in Mice.PloS one · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Maternal obesity affects the incidence of cardiovascular disease and diabetes in offspring. Also the use of assisted reproductive technologies (ART) has been associated with cardiovascular deficiencies in offspring. Obese women often suffer from infertility and use ART to achieve a pregnancy, but the combined effects of maternal obesity and ART on cardiovascular health and incidence of diabetes in the offspring is not known. Here, we report the effects of the use of ART within an obesogenic environment, consisting of feeding a western diet (WD) to dams and offspring, on resistance artery function and presence of diabetes biomarkers in juvenile mice offspring. Our results indicate that WD and ART interacted to induce endothelial dysfunction in mesenteric resistance arteries isolated from 7-week-old mice offspring. This was determined by presence of a reduced acetylcholine-induced dilation compared to controls. The arteries from these WD-ART mice also had greater wall cross-sectional areas and wall to lumen ratios indicative of vascular hypertrophic remodeling. Of the diabetes biomarkers measured, only resistin was affected by a WD×ART interaction. Serum resistin was significantly greater in WD-ART offspring compared to controls. Diet and sex effects were observed in other diabetes biomarkers. Our conclusion is that in mice the use of ART within an obesogenic environment interacts to favor the development of endothelial dysfunction in the resistance arteries of juvenile offspring, while having marginal effects on diabetes biomarkers.
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