ArticlePloS one2014
A three-dimensional computational model of collagen network mechanics.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.PLoS computational biology · 2025Article
- Virtual testing methodology to predict the mechanical behavior of collagen hydrogels from nanoarchitecture.Materials today. Bio · 2025Article
- Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.Journal of microscopy · 2025Article
- Understanding the effects of mineralization and structure on the mechanical properties of tendon-bone insertion using mesoscale computational modeling.Journal of the mechanical behavior of biomedical materials · 2024Article
- Fibre crosslinking drives the emergence of order in a three-dimensional dynamical network model.Royal Society open science · 2024Article
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- Hybrid cellular Potts and bead-spring modeling of cells in fibrous extracellular matrix.Biophysical journal · 2023Article
- Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.Journal of the Royal Society, Interface · 2022Article
- Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies.Molecular and cellular biology · 2021Article
- A computational framework for modeling cell-matrix interactions in soft biological tissues.Biomechanics and modeling in mechanobiology · 2021Article
- Joining soft tissues to bone: Insights from modeling and simulations.Bone reports · 2021Review
- Long-range mechanical signaling in biological systems.Soft matter · 2021Review
- Evaluation of Cell's Passability in the ECM Network.Biophysical journal · 2020Article
- Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load.Acta biomaterialia · 2019Article
- Combined experimental and computational characterization of crosslinked collagen-based hydrogels.PloS one · 2018Article
- The sulfilimine cross-link of collagen IV contributes to kidney tubular basement membrane stiffness.American journal of physiology. Renal physiology · 2017Article
- Mathematical model of chronic pancreatitis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanical Cell-Cell Communication in Fibrous Networks: The Importance of Network Geometry.Bulletin of mathematical biology · 2017Article
- Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Mechanosensing via cell-matrix adhesions in 3D microenvironments.Experimental cell research · 2016Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Extracellular matrix (ECM) strongly influences cellular behaviors, including cell proliferation, adhesion, and particularly migration. In cancer, the rigidity of the stromal collagen environment is thought to control tumor aggressiveness, and collagen alignment has been linked to tumor cell invasion. While the mechanical properties of collagen at both the single fiber scale and the bulk gel scale are quite well studied, how the fiber network responds to local stress or deformation, both structurally and mechanically, is poorly understood. This intermediate scale knowledge is important to understanding cell-ECM interactions and is the focus of this study. We have developed a three-dimensional elastic collagen fiber network model (bead-and-spring model) and studied fiber network behaviors for various biophysical conditions: collagen density, crosslinker strength, crosslinker density, and fiber orientation (random vs. prealigned). We found the best-fit crosslinker parameter values using shear simulation tests in a small strain region. Using this calibrated collagen model, we simulated both shear and tensile tests in a large linear strain region for different network geometry conditions. The results suggest that network geometry is a key determinant of the mechanical properties of the fiber network. We further demonstrated how the fiber network structure and mechanics evolves with a local formation, mimicking the effect of pulling by a pseudopod during cell migration. Our computational fiber network model is a step toward a full biomechanical model of cellular behaviors in various ECM conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.