ReviewJournal of clinical and diagnostic research : JCDR2014
Enamel regeneration - current progress and challenges.
Review in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair.Frontiers in bioengineering and biotechnology · 2026Article
- Regenerative Strategies in Pediatric Dentistry: A Comprehensive Overview of Tissue Engineering from Past to Future.Advances in experimental medicine and biology · 2026Review
- Review
- Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges.Tissue engineering and regenerative medicine · 2025Review
- Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction.The Saudi dental journal · 2024Review
- Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges-A Narrative Review.Scientifica · 2024Review
- Documenting the Anisotropic Stiffness of Hard Tissues with Resonant Ultrasound Spectroscopy.Advances in experimental medicine and biology · 2022Review
- A Pilot Study on High Wavenumber Raman Analysis of Human Dental Tissues.Journal of Raman spectroscopy : JRS · 2020Article
- Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update.Stem cells international · 2020Review
- Amelogenic transcriptome profiling in ameloblast-like cells derived from adult gingival epithelial cells.Scientific reports · 2019Article
- Stem cells and tooth regeneration: prospects for personalized dentistry.The EPMA journal · 2019Review
- Enamel biomimetics-fiction or future of dentistry.International journal of oral science · 2019Review
- DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Physiological reviews · 2017Review
- Nanomaterials for Tissue Engineering In Dentistry.Nanomaterials (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental Enamel is the outermost covering of teeth. It is hardest mineralized tissue present in the human body. Enamel faces the challenge of maintaining its integrity in a constant demineralization and remineralization within the oral environment and it is vulnerable to wear, damage, and decay. It cannot regenerate itself, because it is formed by a layer of cells that are lost after the tooth eruption. Conventional treatment relies on synthetic materials to restore lost enamel that cannot mimic natural enamel. With advances in material science and understanding of basic principles of organic matrix mediated mineralization paves a way for formation of synthetic enamel. The knowledge of enamel formation and understanding of protein interactions and their gene products function along with the isolation of postnatal stem cells from various sources in the oral cavity, and the development of smart materials for cell and growth factor delivery, makes possibility for biological based enamel regeneration. This article will review the recent endeavor on biomimetic synthesis and cell based strategies for enamel regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.