ArticleAvicenna journal of phytomedicine2014
Effects of Hypericum perforatum extract on IgG titer, leukocytes subset and spleen index in rats.
Article in Avicenna journal of phytomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Influence of black garlic and Hypericum scabrum on growth performance, fecal microbiota, diarrhea, oxidative stress and immune status in pre-weaning calves.Tropical animal health and production · 2026Article
- Evaluation of the Antioxidant Status of Ethanolic Extract of Hypericum perforatum and Its Effect on Performance, Immune System, Antioxidant Status and Plasma Biochemical Indices of Broiler Chickens.Veterinary medicine and science · 2026Article
- Effects of infliximab, an anti-TNF-α, on cyclophosphamide-induced bone marrow toxicity.Cancer chemotherapy and pharmacology · 2025Article
- The Influence of Ethanolic Extract of Hypericum Perforatum (St. John's wort) on Growth Performance, Serum Metabolites, Fat Deposition, Immunity, and Lipid Peroxidation in Broiler Chickens.Veterinary medicine and science · 2025Article
- Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Immunomodulatory Potential of the IndustrializedFoods (Basel, Switzerland) · 2021Article
- Rationale for Dietary Antioxidant Treatment of ADHD.Nutrients · 2018Review
- Effects of Hypericum scabrum extract on learning and memory and oxidant/antioxidant status in rats fed a long-term high-fat diet.Metabolic brain disease · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHypericum perforatum L. is a medicinal plant containing many polyphenolic compounds, including flavonoids and phenolic acids with antidepressant and anti-inflammatory properties. This study was investigated the effects of Hypericum perforatum extract (HPE) on immunity, body weight (BW), and spleen index (SI) in rats. MATERIALS AND
methodsA total of 24 Wistar male rats were randomly received 4 different doses (6 rats each) of HPE (0, 100, 200 and 400 mg/kg BW) intraperitoneally for 14 days using a completely randomized design. On days 1 and 7, rats were received 0.5 ml SRBC (10%) injection. Blood samples were collected on day 14 to evaluate IgG titer and leukocyte count. On days 1, 7 and 14, the BW and on day 14 spleen were weighted for SI.
resultsThe IgG titer increased with higher doses of HPE. The HPE increased number of lymphocytes at 200 mg but decreased at 400 mg, number of neutrophils decreased at 200 mg but increased at 400 mg, and number of monocytes increased at 100 mg and 200 mg but decreased at 400 mg (p<0.01). Increasing doses of HPE lowered BW (p<0.01). The HPE increased SI at 100 mg and 200 mg but decreased at 400 mg (p>0.072).
conclusionsThe results showed that HPE slightly improved IgG titer but significantly increased the number of leukocytes and monocytes at 200 mg, and neutrophils at 400 mg. The HPE decreased BW at 100 mg and 200 mg with no damage on spleen.
Indexed as
Identifiers
25386405PMC4224955W2170450045What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.