Evidence map›Paper›PMID 25386401›Full record

ArticleAvicenna journal of phytomedicine2014

Khaya senegalensis inhibits piroxicam mediated gastro-toxicity in wistar rats.

Fatima Nnawodu Ishaq, Abdulkadir Umar Zezi, Temidayo Olutoyin Olurishe

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Article in Avicenna journal of phytomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fatima Nnawodu IshaqDepartment of Pharmacology and Therapeutics, Ahmadu Bello University, P M B 1045, Zaria-Nigeria.
Abdulkadir Umar ZeziDepartment of Pharmacology and Therapeutics, Ahmadu Bello University, P M B 1045, Zaria-Nigeria.
Temidayo Olutoyin OlurisheDepartment of Pharmacology and Therapeutics, Ahmadu Bello University, P M B 1045, Zaria-Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. MATERIALS AND

methodsThirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, piroxicam (20 mg/kg), extract (200 and 400 mg/kg) alone and both doses of the extract co-administered with piroxicam. The drugs were administered orally to all the rats for fourteen consecutive days and on the fifteenth day, they were euthanized with chloroform inhalation. Blood samples and the stomachs were isolated for evaluation of the oxidative stress biomarkers and gastro integrity, respectively.

resultsThe results of the study revealed that the levels of oxidative stress markers didn't differ significantly between the groups receiving the extract alone, the extract in combination or piroxicam alone. Gross and histological observations of the stomach showed gastric mucosal changes and mild atrophic lesions in the piroxicam group only.

conclusionThis study illustrates the interaction of Khaya senegalensis and piroxicam results in the gastro-protective beneficial effects. The extract's outcome on various prostaglandin levels and synthesis is being considered towards possible elucidation regarding the exact mechanism of cytoprotection.

Indexed as

Drug interactionGastro-toxicityKhaya senegalensisPiroxicam

Identifiers

PMID25386401
PMCPMC4224951

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