Evidence map›Paper›PMID 25386334›Full record

ArticleChemical science2014

Natalamycin A, an Ansamycin from a Termite-Associated

Ki Hyun Kim, Timothy R Ramadhar, Christine Beemelmanns, Shugeng Cao, Michael Poulsen, Cameron R Currie, Jon Clardy

Open access · greenAbstract read
In one paragraph

Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  7. Article
  8. Animal Microbiomes as a Source of Novel Antibiotic-Producing Strains.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Article
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  14. Review
  15. Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Genome mining for drug discovery: cyclic lipopeptides related to daptomycin.Journal of industrial microbiology & biotechnology · 2021
    Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ki Hyun KimDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, United States of America.
Timothy R RamadharDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, United States of America.
Christine BeemelmannsDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, United States of America.
Shugeng CaoDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, United States of America.
Michael PoulsenDepartment of Bacteriology, University of Wisconsin-Madison, 6145 Microbial Science Building, 1550 Linden Drive, Madison, Wisconsin, 53706, United States of America.
Cameron R CurrieDepartment of Bacteriology, University of Wisconsin-Madison, 6145 Microbial Science Building, 1550 Linden Drive, Madison, Wisconsin, 53706, United States of America.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, United States of America.
Harvard University · USUniversity of Wisconsin–Madison · US

Funding

Metabolomics driven discovery of drug leads from symbiotic bacteriaU19AI109673 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, CURRIE, CAMERON ROBERT · 2014 to 2018
$16.2M
Molecule-to-gene approaches to new natural productsR01GM086258 · NIGMS · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2008 to 2016
$3.6M
Discovery of natural product-based drugs from bacterial symbionts of insectsRC4GM096347 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CURRIE, CAMERON ROBERT · 2010 to 2010
$2.5M
Discovery of Potential Therapeutic Agents from Insect-Associated Symbiotic BacterF32GM108415 · NIGMS · HARVARD MEDICAL SCHOOL · PI RAMADHAR, TIMOTHY RAMESAR · 2014 to 2015
$106k
NIAID NIH HHS U19 AI109673NIGMS NIH HHS F32 GM108415NIGMS NIH HHS R01 GM086258NIGMS NIH HHS RC4 GM096347
6 · The paper itself

Abstract

We report a preliminary functional and complete structural characterization of a highly unusual geldanamycin analog, natalamycin A, that was isolated from

Identifiers

PMID25386334
PMCPMC4224317
OpenAlexW2166409486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.