Evidence map›Paper›PMID 25386230›Full record

ArticleJournal of oral & maxillofacial research2014

The influence of 1α.25-dihydroxyvitamin d3 coating on implant osseointegration in the rabbit tibia.

Yoshihito Naito, Ryo Jimbo, Matthew S Bryington, Stefan Vandeweghe, Bruno R Chrcanovic, Nick Tovar, Tetsuo Ichikawa, Coelho Paulo G, Ann Wennerberg

Abstract read
In one paragraph

Article in Journal of oral & maxillofacial research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Vitamin D deficiency in early implant failure: two case reports.International journal of implant dentistry · 2016
    Article
  10. Article
  11. Article
  12. Article
  13. Osteonecrosis of the Jaw in Post-Bariatric Patients: An Underestimated Risk in Oral Surgery? Clinical Implications and Perspectives.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshihito Naitoepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö Sweden. ; Department of Oral and Maxillofacial Prosthodontics and Oral Implantology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima Japan.
Ryo Jimboepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö Sweden. ; Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki Japan.
Matthew S BryingtonDepartment of Restorative Dentistry, West Virginia University School of Dentistry, Morgantown, West Virginia USA.
Stefan VandewegheDepartment of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health sciences, University of Ghent Belgium.
Bruno R Chrcanovicepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö Sweden.
Nick TovarDepartment of Biomaterials and Biomimetics, New York University, New York USA.
Tetsuo Ichikawaepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö Sweden.
Coelho Paulo GDepartment of Biomaterials and Biomimetics, New York University, New York USA.
Ann Wennerbergepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to evaluate bone response to an implant surface modified by 1α,25-dihydroxyvitamin D3 [1.25-(OH)2D3] in vivo and the potential link between 1.25-(OH) 2D3 surface concentration and bone response. MATERIAL AND

methodsTwenty-eight implants were divided into 4 groups (1 uncoated control, 3 groups coated with 1.25-(OH)2D3 in concentrations of 10(-8), 10(-7) and 10(-6) M respectively), placed in the rabbit tibia for 6 weeks. Topographical analyses were carried out on coated and uncoated discs using interferometer and atomic-force-microscope (AFM). Twenty-eight implants were histologically observed (bone-to-implant-contact [BIC] and new-bone-area [NBA]).

resultsThe results showed that the 1.25-(OH)2D3 coated implants presented a tendency to osseointegrate better than the non-coated surfaces, the differences were not significant (P > 0.05).

conclusionsThe effect of 1.25-(OH)2D3 coating to implants suggested possible dose dependent effects, however no statistical differences could be found. It is thought that the base substrate topography (turned) could not sustain sufficient amount of 1.25-(OH)2D3 enough to present significant biologic responses. Thus, development a base substrate that can sustain 1.25-(OH)2D3 for a long period is necessary in future studies.

Indexed as

bone formationdental implantsdrug dose response relationshiphistological techniquesvitamin D

Identifiers

PMID25386230
PMCPMC4219862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.