ArticleFrontiers in neurology2014
The dynamics of the epileptic brain reveal long-memory processes.
Article in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Quantifying cognitive effort's impact on suppression of epilepsy-associated after discharges.Frontiers in network physiology · 2026Article
- Article
- Dynamic multiday seizure cycles and evolving rhythms in a tetanus toxin rat model of epilepsy.Scientific reports · 2025Article
- Cycles in seizure duration and their underlying dynamics in the tetanus toxin rat model.Brain communications · 2025Article
- Seizure forecasting: Bifurcations in the long and winding road.Epilepsia · 2023Review
- The role of long-term power-law memory in controlling large-scale dynamical networks.Scientific reports · 2023Article
- Computational modeling allows unsupervised classification of epileptic brain states across species.Scientific reports · 2023Article
- EEG datasets for seizure detection and prediction- A review.Epilepsia open · 2023Review
- Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating.Physics in medicine and biology · 2023Article
- A Bayesian switching linear dynamical system for estimating seizure chronotypes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cycles in epilepsy.Nature reviews. Neurology · 2021Review
- Evidence for long memory in focal seizure duration.Epilepsia open · 2021Article
- Forecasting seizure risk in adults with focal epilepsy: a development and validation study.The Lancet. Neurology · 2021Article
- The Challenging Path to Developing a Mobile Health Device for Epilepsy: The Current Landscape and Where We Go From Here.Frontiers in neurology · 2021Review
- The syndrome of transient epileptic amnesia: a combined series of 115 cases and literature review.Brain communications · 2021Article
- Epileptic Seizure Cycles: Six Common Clinical Misconceptions.Frontiers in neurology · 2021Article
- More Than Spikes: On the Added Value of Non-linear Intracranial EEG Analysis for Surgery Planning in Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Critical slowing down as a biomarker for seizure susceptibility.Nature communications · 2020Article
- Natural variability in seizure frequency: Implications for trials and placebo.Epilepsy research · 2020Article
- Why Brain Criticality Is Clinically Relevant: A Scoping Review.Frontiers in neural circuits · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern of epileptic seizures is often considered unpredictable and the interval between events without correlation. A number of studies have examined the possibility that seizure activity respects a power-law relationship, both in terms of event magnitude and inter-event intervals. Such relationships are found in a variety of natural and man-made systems, such as earthquakes or Internet traffic, and describe the relationship between the magnitude of an event and the number of events. We postulated that human inter-seizure intervals would follow a power-law relationship, and furthermore that evidence for the existence of a long-memory process could be established in this relationship. We performed a post hoc analysis, studying eight patients who had long-term (up to 2 years) ambulatory intracranial EEG data recorded as part of the assessment of a novel seizure prediction device. We demonstrated that a power-law relationship could be established in these patients (β = - 1.5). In five out of the six subjects whose data were sufficiently stationary for analysis, we found evidence of long memory between epileptic events. This memory spans time scales from 30 min to 40 days. The estimated Hurst exponents range from 0.51 to 0.77 ± 0.01. This finding may provide evidence of phase-transitions underlying the dynamics of epilepsy.
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