ArticleNanoscale research letters2014
A promising gene delivery system developed from PEGylated MoS2 nanosheets for gene therapy.
Article in Nanoscale research letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
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- Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Biodegradable FePSJournal of nanobiotechnology · 2023Article
- MoSBioactive materials · 2021Review
- Article
- Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?International journal of nanomedicine · 2020Review
- Two-Dimensional Transition Metal Dichalcogenides: Synthesis, Biomedical Applications and Biosafety Evaluation.Frontiers in bioengineering and biotechnology · 2020Review
- Two-Dimensional Nanosheet-Based Photonic Nanomedicine for Combined Gene and Photothermal Therapy.Frontiers in pharmacology · 2019Review
- Mass spectrometry imaging of the in situ drug release from nanocarriers.Science advances · 2018Article
- Applications of Nanosheets in Frontier Cellular Research.Nanomaterials (Basel, Switzerland) · 2018Review
- Fabrication of ultrasmall WSOncoTargets and therapy · 2018Article
- Trigger-Responsive Gene Transporters for Anticancer Therapy.Nanomaterials (Basel, Switzerland) · 2017Review
- Robust Denaturation of Villin Headpiece by MoS2 Nanosheet: Potential Molecular Origin of the Nanotoxicity.Scientific reports · 2016Article
- Biological and environmental interactions of emerging two-dimensional nanomaterials.Chemical Society reviews · 2016Review
- Review
- Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy.Scientific reports · 2015Article
- Effect of Doping on Hydrogen Evolution Reaction of Vanadium Disulfide Monolayer.Nanoscale research letters · 2015Article
- PEG-PEI/siROCK2 Protects Against Aβ42-Induced Neurotoxicity in Primary Neuron Cells for Alzheimer Disease.Cellular and molecular neurobiology · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new class of two-dimensional (2D) nanomaterial, transition metal dichalcogenides (TMDCs) such as MoS2, MoSe2, WS2, and WSe2 which have fantastic physical and chemical properties, has drawn tremendous attention in different fields recently. Herein, we for the first time take advantage of the great potential of MoS2 with well-engineered surface as a novel type of 2D nanocarriers for gene delivery and therapy of cancer. In our system, positively charged MoS2-PEG-PEI is synthesized with lipoic acid-modified polyethylene glycol (LA-PEG) and branched polyethylenimine (PEI). The amino end of positively charged nanomaterials can bind to the negatively charged small interfering RNA (siRNA). After detection of physical and chemical characteristics of the nanomaterial, cell toxicity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Polo-like kinase 1 (PLK1) was investigated as a well-known oncogene, which was a critical regulator of cell cycle transmission at multiple levels. Through knockdown of PLK1 with siRNA carried by novel nanovector, qPCR and Western blot were used to measure the interfering efficiency; apoptosis assay was used to detect the transfection effect of PLK1. All results showed that the novel nanocarrier revealed good biocompatibility, reduced cytotoxicity, as well as high gene-carrying ability without serum interference, thus would have great potential for gene delivery and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.